Detalhe da pesquisa
1.
Liposome-encapsulated mannose-1-phosphate therapy improves global N-glycosylation in different congenital disorders of glycosylation.
Mol Genet Metab
; 142(2): 108487, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38733638
2.
An orally administered enzyme therapeutic for homocystinuria that suppresses homocysteine by metabolizing methionine in the gastrointestinal tract.
Mol Genet Metab
; 139(4): 107653, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37463544
3.
Oral enzyme therapy for maple syrup urine disease (MSUD) suppresses plasma leucine levels in intermediate MSUD mice and healthy nonhuman primates.
J Inherit Metab Dis
; 46(6): 1089-1103, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37494004
4.
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
Bioorg Med Chem Lett
; 89: 129277, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37105490
5.
Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.
Pharm Res
; 34(11): 2403-2414, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28815392
6.
Optimizing human α-galactosidase for treatment of Fabry disease.
Sci Rep
; 13(1): 4748, 2023 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36959353
7.
Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
Sci Signal
; 8(405): ra122, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26628680