Detalhe da pesquisa
1.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 179(2): 417-431.e19, 2019 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31585081
2.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 180(2): 406, 2020 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31978350
3.
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
J Allergy Clin Immunol
; 150(4): 972-978.e7, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35487308
4.
A CEACAM6-High Airway Neutrophil Phenotype and CEACAM6-High Epithelial Cells Are Features of Severe Asthma.
J Immunol
; 198(8): 3307-3317, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28275137
5.
Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation.
J Immunol
; 195(3): 953-64, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26116508
6.
Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts.
J Immunol
; 193(1): 111-9, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24879793
7.
Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines.
J Biol Chem
; 288(37): 26583-93, 2013 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23880771
8.
LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies.
J Biol Chem
; 287(52): 43331-9, 2012 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23118228
9.
Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma.
J Allergy Clin Immunol
; 129(1): 104-11.e1-9, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21975173
10.
An agonistic anti-signal regulatory protein α antibody for chronic inflammatory diseases.
Cell Rep Med
; 4(8): 101130, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37490914
11.
Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model.
Am J Pathol
; 179(4): 1667-80, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21819959
12.
Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.
Sci Transl Med
; 14(675): eabp9159, 2022 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36516271
13.
Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling.
J Biol Chem
; 285(27): 20850-9, 2010 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20444694
14.
Bivalent antibody pliers inhibit ß-tryptase by an allosteric mechanism dependent on the IgG hinge.
Nat Commun
; 11(1): 6435, 2020 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33353951
15.
Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma.
Sci Transl Med
; 10(468)2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30463918
16.
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.
Sci Transl Med
; 7(301): 301ra129, 2015 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26290411
17.
Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
Sci Signal
; 8(405): ra122, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26628680
18.
Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.
J Clin Invest
; 120(6): 2218-29, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20458139