Detalhe da pesquisa
1.
Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J Biol Chem
; 285(5): 3417-27, 2010 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-19923222
2.
Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.
Proc Natl Acad Sci U S A
; 105(25): 8754-9, 2008 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18559859
3.
Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid.
J Neurotrauma
; 37(13): 1574-1586, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31973644
4.
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
J Pharmacol Exp Ther
; 331(2): 598-608, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19671883
5.
(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.
Bioorg Med Chem Lett
; 19(3): 926-9, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19097890
6.
Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse.
Neurodegener Dis
; 5(2): 65-71, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18182780
7.
Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.
J Neurosci
; 25(39): 8898-902, 2005 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16192379
8.
Expression of NALP1 in cerebellar granule neurons stimulates apoptosis.
Cell Signal
; 16(9): 1013-21, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15212762
9.
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Front Neurol
; 6: 178, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26388830
10.
Alzheimer's disease: an overview of current and emerging therapeutic strategies.
Curr Top Med Chem
; 2(4): 343-52, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11966458
11.
Commentary on "a roadmap for the prevention of dementia II: Leon Thal Symposium 2008." A proposal to increase participation in Alzheimer's disease clinical trials.
Alzheimers Dement
; 5(2): 140-2, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19328445
12.
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
J Med Chem
; 51(23): 7348-51, 2008 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19012391
13.
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease.
Proc Natl Acad Sci U S A
; 103(13): 5161-6, 2006 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16549764
14.
Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase.
Cytometry A
; 69(11): 1123-31, 2006 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17051583
15.
Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease.
NeuroRx
; 2(4): 612-26, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16489369
16.
Functional characterization of Narc 1, a novel proteinase related to proteinase K.
Arch Biochem Biophys
; 420(1): 55-67, 2003 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14622975