Detalhe da pesquisa
1.
PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors.
Proc Natl Acad Sci U S A
; 114(46): 12249-12254, 2017 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29087303
2.
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.
Nat Med
; 13(9): 1070-7, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17767167
3.
A paracrine requirement for hedgehog signalling in cancer.
Nature
; 455(7211): 406-10, 2008 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-18754008
4.
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
J Med Chem
; 67(2): 1262-1313, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38180485
5.
Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients.
Nat Commun
; 11(1): 5551, 2020 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33144586
6.
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib.
J Clin Oncol
; 23(25): 5900-9, 2005 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16043828
7.
Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients.
Clin Cancer Res
; 11(24 Pt 1): 8686-98, 2005 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16361555
8.
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.
Cancer Cell
; 27(3): 327-41, 2015 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25759019
9.
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance.
Cancer Res
; 71(2): 435-44, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21123452
10.
TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer.
Sci Signal
; 4(177): ra41, 2011 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21673316
11.
miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer.
Sci Signal
; 4(186): pt5, 2011 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21868360
12.
CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma.
Sci Transl Med
; 3(74): 74ra22, 2011 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21411738
13.
Clinical activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer.
J Clin Oncol
; 28(7): 1215-23, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19901115
14.
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
Science
; 326(5952): 572-4, 2009 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19726788