Detalhe da pesquisa
1.
Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model.
Proc Natl Acad Sci U S A
; 114(12): 3151-3156, 2017 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28265066
2.
N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer.
Cell Rep Med
; 4(4): 101002, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37044095
3.
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorg Med Chem
; 20(22): 6770-89, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23018093
4.
The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells.
EMBO Mol Med
; 13(4): e13162, 2021 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33751828
5.
Deciphering mechanisms of response and resistance in large-scale mouse cancer screens.
Curr Opin Genet Dev
; 54: 48-54, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30954760
6.
NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models.
Breast Cancer Res
; 10(2): R33, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18430202
7.
Targeting Hsp90 for the treatment of cancer.
Curr Opin Drug Discov Devel
; 9(4): 483-95, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16889231
8.
The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth.
Mol Cancer Ther
; 12(6): 890-900, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23493311
9.
Toward the optimization of stent-based treatment for coronary artery disease.
Curr Opin Drug Discov Devel
; 13(2): 157-8, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20205049
10.
Hsp90 inhibitors: clinical development and future opportunities in oncology therapy.
Curr Opin Drug Discov Devel
; 13(2): 193-202, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20205053
11.
Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.
Mol Cancer Ther
; 9(4): 906-19, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20371713
12.
(89)Zr-trastuzumab PET visualises HER2 downregulation by the HSP90 inhibitor NVP-AUY922 in a human tumour xenograft.
Eur J Cancer
; 46(3): 678-84, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20036116
13.
Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.
J Med Chem
; 52(15): 4794-809, 2009 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19610616
14.
E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes.
EMBO J
; 22(23): 6289-98, 2003 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14633988
15.
Reduced hepatic tumor incidence in cyclin G1-deficient mice.
Hepatology
; 37(4): 862-70, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12668979
16.
OVCA1: emerging as a bona fide tumor suppressor.
Genes Dev
; 18(3): 245-8, 2004 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14871925