Detalhe da pesquisa
1.
Extraislet expression of islet antigen boosts T cell exhaustion to partially prevent autoimmune diabetes.
Proc Natl Acad Sci U S A
; 121(6): e2315419121, 2024 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38285952
2.
Altering ß Cell Antigen Exposure to Exhausted CD8+ T Cells Prevents Autoimmune Diabetes in Mice.
J Immunol
; 212(11): 1658-1669, 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38587315
3.
Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice.
Diabetologia
; 64(4): 878-889, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33483762
4.
Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes.
J Immunol
; 192(2): 572-80, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24337380
5.
TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes.
Front Immunol
; 15: 1370907, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38533515
6.
Diabetes induced by checkpoint inhibition in nonobese diabetic mice can be prevented or reversed by a JAK1/JAK2 inhibitor.
Clin Transl Immunology
; 11(11): e1425, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36325490
7.
Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse.
Cell Rep
; 39(4): 110747, 2022 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35476975
8.
A Pro-Endocrine Pancreatic Islet Transcriptional Program Established During Development Is Retained in Human Gallbladder Epithelial Cells.
Cell Mol Gastroenterol Hepatol
; 13(5): 1530-1553.e4, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35032693
9.
Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice.
Front Immunol
; 12: 645817, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33841427
10.
The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-γ and Common γ Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice.
Front Immunol
; 11: 588543, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33343569
11.
IL-21 regulates SOCS1 expression in autoreactive CD8+ T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice.
Sci Rep
; 9(1): 15302, 2019 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31653894
12.
Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro.
Hum Immunol
; 69(9): 543-51, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18639598
13.
NF-κB is weakly activated in the NOD mouse model of type 1 diabetes.
Sci Rep
; 8(1): 4217, 2018 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29523846
14.
Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.
Diabetes
; 66(12): 3041-3050, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28733313
15.
Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes.
JCI Insight
; 1(10): e86065, 2016 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27699217
16.
BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells.
Diabetes
; 64(9): 3229-38, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25948683
17.
Complete diabetes protection despite delayed thymic tolerance in NOD8.3 TCR transgenic mice due to antigen-induced extrathymic deletion of T cells.
Diabetes
; 61(2): 425-35, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22190647