Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.

Crawford, James J; Feng, Jianwen; Brightbill, Hans D; Johnson, Adam R; Wright, Matthew; Kolesnikov, Aleksandr; Lee, Wendy; Castanedo, Georgette M; Do, Steven; Blaquiere, Nicole; Staben, Steven T; Chiang, Po-Chang; Fan, Peter W; Baumgardner, Matt; Wong, Susan; Godemann, Robert; Grabbe, Alice; Wiegel, Catharina; Sujatha-Bhaskar, Swathi; Hymowitz, Sarah G; Liau, Nicholas; Hsu, Peter L; McEwan, Paul A; Ismaili, Moulay Hicham Alaoui; Landry, Matthew L.

Bioorg Med Chem Lett ; 89: 129277, 2023 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-37105490

2.

Computational analysis of kinase inhibitor selectivity using structural knowledge.

Lo, Yu-Chen; Liu, Tianyun; Morrissey, Kari M; Kakiuchi-Kiyota, Satoko; Johnson, Adam R; Broccatelli, Fabio; Zhong, Yu; Joshi, Amita; Altman, Russ B.

Bioinformatics ; 35(2): 235-242, 2019 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-29985971

3.

Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL.

Reiff, Sean D; Muhowski, Elizabeth M; Guinn, Daphne; Lehman, Amy; Fabian, Catherine A; Cheney, Carolyn; Mantel, Rose; Smith, Lisa; Johnson, Amy J; Young, Wendy B; Johnson, Adam R; Liu, Lichuan; Byrd, John C; Woyach, Jennifer A.

Blood ; 132(10): 1039-1049, 2018 09 06.

Artigo em Inglês | MEDLINE | ID: mdl-30018078

4.

Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.

Erickson, Rebecca I; Schutt, Leah K; Tarrant, Jacqueline M; McDowell, Michelle; Liu, Lichuan; Johnson, Adam R; Lewin-Koh, Sock-Cheng; Hedehus, Maj; Ross, Jed; Carano, Richard A D; Staflin, Karin; Zhong, Fiona; Crawford, James J; Zhong, Shelly; Reif, Karin; Katewa, Arna; Wong, Harvey; Young, Wendy B; Dambach, Donna M; Misner, Dinah L.

J Pharmacol Exp Ther ; 360(1): 226-238, 2017 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-27821712

5.

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

Wertz, Ingrid E; Kusam, Saritha; Lam, Cynthia; Okamoto, Toru; Sandoval, Wendy; Anderson, Daniel J; Helgason, Elizabeth; Ernst, James A; Eby, Mike; Liu, Jinfeng; Belmont, Lisa D; Kaminker, Josh S; O'Rourke, Karen M; Pujara, Kanan; Kohli, Pawan Bir; Johnson, Adam R; Chiu, Mark L; Lill, Jennie R; Jackson, Peter K; Fairbrother, Wayne J; Seshagiri, Somasekar; Ludlam, Mary J C; Leong, Kevin G; Dueber, Erin C; Maecker, Heather; Huang, David C S; Dixit, Vishva M.

Nature ; 471(7336): 110-4, 2011 Mar 03.

Artigo em Inglês | MEDLINE | ID: mdl-21368834

6.

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.

Lupardus, Patrick J; Ultsch, Mark; Wallweber, Heidi; Bir Kohli, Pawan; Johnson, Adam R; Eigenbrot, Charles.

Proc Natl Acad Sci U S A ; 111(22): 8025-30, 2014 Jun 03.

Artigo em Inglês | MEDLINE | ID: mdl-24843152

7.

Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties.

René, Olivier; Fauber, Benjamin P; Barnard, Adrian; Chapman, Kerry; Deng, Yuzhong; Eidenschenk, Céline; Everett, Christine; Gobbi, Alberto; Johnson, Adam R; La, Hank; Norman, Maxine; Salmon, Gary; Summerhill, Susan; Wong, Harvey.

Bioorg Med Chem Lett ; 26(18): 4455-4461, 2016 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-27524313

8.

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.

Young, Wendy B; Barbosa, James; Blomgren, Peter; Bremer, Meire C; Crawford, James J; Dambach, Donna; Eigenbrot, Charles; Gallion, Steve; Johnson, Adam R; Kropf, Jeffrey E; Lee, Seung H; Liu, Lichuan; Lubach, Joseph W; Macaluso, Jen; Maciejewski, Pat; Mitchell, Scott A; Ortwine, Daniel F; Di Paolo, Julie; Reif, Karin; Scheerens, Heleen; Schmitt, Aaron; Wang, Xiaojing; Wong, Harvey; Xiong, Jin-Ming; Xu, Jianjun; Yu, Christine; Zhao, Zhongdong; Currie, Kevin S.

Bioorg Med Chem Lett ; 26(2): 575-579, 2016 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-26675441

9.

Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.

Fauber, Benjamin P; Gobbi, Alberto; Savy, Pascal; Burton, Brenda; Deng, Yuzhong; Everett, Christine; La, Hank; Johnson, Adam R; Lockey, Peter; Norman, Maxine; Wong, Harvey.

Bioorg Med Chem Lett ; 25(19): 4109-13, 2015 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-26321361

10.

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.

Fauber, Benjamin P; Gobbi, Alberto; Robarge, Kirk; Zhou, Aihe; Barnard, Adrian; Cao, Jianhua; Deng, Yuzhong; Eidenschenk, Céline; Everett, Christine; Ganguli, Arunima; Hawkins, Julie; Johnson, Adam R; La, Hank; Norman, Maxine; Salmon, Gary; Summerhill, Susan; Ouyang, Wenjun; Tang, Wei; Wong, Harvey.

Bioorg Med Chem Lett ; 25(15): 2907-12, 2015 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-26048793

11.

A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.

Sohn, Sue J; Barrett, Kathy; Van Abbema, Anne; Chang, Christine; Kohli, Pawan Bir; Kanda, Hidenobu; Smith, Janice; Lai, Yingjie; Zhou, Aihe; Zhang, Birong; Yang, Wenqian; Williams, Karen; Macleod, Calum; Hurley, Christopher A; Kulagowski, Janusz J; Lewin-Koh, Nicholas; Dengler, Hart S; Johnson, Adam R; Ghilardi, Nico; Zak, Mark; Liang, Jun; Blair, Wade S; Magnuson, Steven; Wu, Lawren C.

J Immunol ; 191(5): 2205-16, 2013 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-23894201

12.

Image processing for cameras with fiber bundle image relay.

Olivas, Stephen J; Arianpour, Ashkan; Stamenov, Igor; Morrison, Rick; Stack, Ron A; Johnson, Adam R; Agurok, Ilya P; Ford, Joseph E.

Appl Opt ; 54(5): 1124-37, 2015 Feb 10.

Artigo em Inglês | MEDLINE | ID: mdl-25968031

13.

Panoramic monocentric imaging using fiber-coupled focal planes.

Stamenov, Igor; Arianpour, Ashkan; Olivas, Stephen J; Agurok, Ilya P; Johnson, Adam R; Stack, Ronald A; Morrison, Rick L; Ford, Joseph E.

Opt Express ; 22(26): 31708-21, 2014 Dec 29.

Artigo em Inglês | MEDLINE | ID: mdl-25607140

14.

Identification of tertiary sulfonamides as RORc inverse agonists.

Fauber, Benjamin P; René, Olivier; Burton, Brenda; Everett, Christine; Gobbi, Alberto; Hawkins, Julie; Johnson, Adam R; Liimatta, Marya; Lockey, Peter; Norman, Maxine; Wong, Harvey.

Bioorg Med Chem Lett ; 24(9): 2182-7, 2014 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-24685544

15.

Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.

Fauber, Benjamin P; René, Olivier; de Leon Boenig, Gladys; Burton, Brenda; Deng, Yuzhong; Eidenschenk, Céline; Everett, Christine; Gobbi, Alberto; Hymowitz, Sarah G; Johnson, Adam R; La, Hank; Liimatta, Marya; Lockey, Peter; Norman, Maxine; Ouyang, Wenjun; Wang, Weiru; Wong, Harvey.

Bioorg Med Chem Lett ; 24(16): 3891-7, 2014 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-25017032

16.

A reversed sulfonamide series of selective RORc inverse agonists.

van Niel, Monique B; Fauber, Benjamin P; Cartwright, Matthew; Gaines, Simon; Killen, Jonathan C; René, Olivier; Ward, Stuart I; de Leon Boenig, Gladys; Deng, Yuzhong; Eidenschenk, Céline; Everett, Christine; Gancia, Emanuela; Ganguli, Arunima; Gobbi, Alberto; Hawkins, Julie; Johnson, Adam R; Kiefer, James R; La, Hank; Lockey, Peter; Norman, Maxine; Ouyang, Wenjun; Qin, Ann; Wakes, Nicole; Waszkowycz, Bohdan; Wong, Harvey.

Bioorg Med Chem Lett ; 24(24): 5769-5776, 2014 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-25453817

17.

Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.

Terrett, Jack A; Ly, Justin Q; Katavolos, Paula; Hasselgren, Catrin; Laing, Steven; Zhong, Fiona; Villemure, Elisia; Déry, Martin; Larouche-Gauthier, Robin; Chen, Huifen; Shore, Daniel G; Lee, Wyne P; Suto, Eric; Johnson, Kevin; Brooks, Marjory; Stablein, Alyssa; Beaumier, Francis; Constantineau-Forget, Léa; Grand-Maître, Chantal; Lépissier, Luce; Ciblat, Stéphane; Sturino, Claudio; Chen, Yong; Hu, Baihua; Elstrott, Justin; Gandham, Vineela; Joseph, Victory; Booler, Helen; Cain, Gary; Chou, Carolina; Fullerton, Aaron; Lepherd, Michelle; Stainton, Shannon; Torres, Elizabeth; Urban, Konnie; Yu, Lanlan; Zhong, Yu; Bao, Linda; Chou, Kang-Jye; Lin, Jessica; Zhang, Wei; La, Hank; Liu, Liling; Mulder, Teresa; Chen, Jun; Chernov-Rogan, Tania; Johnson, Adam R; Hackos, David H; Leahey, Rebecca; Shields, Shannon D.

J Med Chem ; 67(5): 3287-3306, 2024 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-38431835

18.

Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.

Fauber, Benjamin P; de Leon Boenig, Gladys; Burton, Brenda; Eidenschenk, Céline; Everett, Christine; Gobbi, Alberto; Hymowitz, Sarah G; Johnson, Adam R; Liimatta, Marya; Lockey, Peter; Norman, Maxine; Ouyang, Wenjun; René, Olivier; Wong, Harvey.

Bioorg Med Chem Lett ; 23(24): 6604-9, 2013 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-24239186

19.

Crystal structure of bis(3,5-dichloro-2-hydroxybenzyl)(2-methoxyethyl)amine.

Wile, Bradley M; Griffith, Claire L; Johnson, Adam R.

Acta Crystallogr E Crystallogr Commun ; 79(Pt 9): 782-785, 2023 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-37693661

20.

Selective MMP13 inhibitors.

Li, Jie Jack; Johnson, Adam R.

Med Res Rev ; 31(6): 863-94, 2011 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-20196103

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