Detalhe da pesquisa
1.
A potent Lassa virus antiviral targets an arenavirus virulence determinant.
PLoS Pathog
; 14(12): e1007439, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30576397
2.
Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.
Antimicrob Agents Chemother
; 57(4): 1902-12, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23403421
3.
A novel inhibitor of dengue virus replication that targets the capsid protein.
Antimicrob Agents Chemother
; 57(1): 15-25, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23070172
4.
Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice.
Proc Natl Acad Sci U S A
; 107(2): 838-43, 2010 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20080762
5.
Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers.
Antimicrob Agents Chemother
; 56(7): 3582-6, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22526314
6.
Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers.
Antimicrob Agents Chemother
; 56(9): 4900-5, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22777041
7.
Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects.
Antimicrob Agents Chemother
; 54(6): 2560-6, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20385870
8.
ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation.
Antimicrob Agents Chemother
; 53(12): 4999-5009, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19752270
9.
Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L, B5R, and D8L protects mice from lethal vaccinia virus challenge.
J Virol
; 82(7): 3517-29, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18199639
10.
Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor.
Antimicrob Agents Chemother
; 52(5): 1721-7, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18316519
11.
Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses.
Antiviral Res
; 69(2): 86-97, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16343651
12.
Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection.
PLoS One
; 8(4): e61514, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23637845
13.
Evaluation of Lassa antiviral compound ST-193 in a guinea pig model.
Antiviral Res
; 90(1): 70-9, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21371508
14.
Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.
PLoS One
; 6(8): e23237, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21858040
15.
Impact of ST-246® on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice.
Vaccine
; 29(2): 289-303, 2010 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21036130
16.
Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination.
Vaccine
; 26(7): 933-46, 2008 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18226434
17.
Comparison of transformation protocols in Streptococcus gordonii and evaluation of native promoter strength using a multiple-copy plasmid.
Can J Microbiol
; 53(3): 417-26, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17538652
18.
Listeria monocytogenes 10403S HtrA is necessary for resistance to cellular stress and virulence.
Infect Immun
; 74(1): 765-8, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16369036
19.
Development of PLEX, a plasmid-based expression system for production of heterologous gene products by the gram-positive bacteria Streptococcus gordonii.
Protein Expr Purif
; 40(2): 319-26, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15766873
20.
Clinical and microbiological responses of volunteers to combined intranasal and oral inoculation with a Streptococcus gordonii carrier strain intended for future use as a group A streptococcus vaccine.
Infect Immun
; 73(4): 2360-6, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15784582