Detalhe da pesquisa
1.
Mechanisms of Nitrosamine Mutagenicity and Their Relationship to Rodent Carcinogenic Potency.
Chem Res Toxicol
; 37(2): 181-198, 2024 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38316048
2.
Bioactivation and reactivity research advances - 2022 year in review.
Drug Metab Rev
; 55(4): 267-300, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37608698
3.
Biotransformation research advances - 2022 year in review.
Drug Metab Rev
; 55(4): 301-342, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37737116
4.
Mitigating a Bioactivation Liability with an Azetidine-Based Inhibitor of Diacylglycerol Acyltransferase 2 (DGAT2) En Route to the Discovery of the Clinical Candidate Ervogastat.
Chem Res Toxicol
; 36(6): 934-946, 2023 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37148271
5.
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir.
Xenobiotica
; 53(1): 12-24, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36803165
6.
Biotransformation novel advances - 2021 year in review.
Drug Metab Rev
; 54(3): 207-245, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35815654
7.
Future of Biotransformation Science in the Pharmaceutical Industry.
Drug Metab Dispos
; 50(3): 258-267, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34921097
8.
Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans.
Drug Metab Dispos
; 50(5): 576-590, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35153195
9.
Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease.
Drug Metab Dispos
; 2022 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35779864
10.
Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product N-Nitrosamine Impurities.
Chem Res Toxicol
; 35(3): 475-489, 2022 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35212515
11.
Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans.
Xenobiotica
; 52(3): 240-253, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35382680
12.
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™.
Int J Toxicol
; 41(4): 276-290, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35603517
13.
Novel advances in biotransformation and bioactivation research - 2020 year in review.
Drug Metab Rev
; 53(3): 384-433, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33910427
14.
Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey.
J Pharmacol Exp Ther
; 377(1): 169-180, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33509903
15.
Metabolism and excretion of (S)-6-(3-cyclopentyl-2-(4-trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid (PF-04991532), a hepatoselective glucokinase activator, in humans: confirmation of the MIST potential noted in first-in-Human metabolite scouting studies.
Xenobiotica
; 49(12): 1447-1457, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30747552
16.
Predicting toxicities of reactive metabolite-positive drug candidates.
Annu Rev Pharmacol Toxicol
; 55: 35-54, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25292426
17.
Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes.
J Pharmacol Exp Ther
; 365(2): 262-271, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29440451
18.
6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to ß-Estradiol.
Drug Metab Dispos
; 46(12): 1836-1846, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30194276
19.
Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor.
Xenobiotica
; 48(7): 647-655, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28685622
20.
Selective Activation of AMPK ß1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
J Pharmacol Exp Ther
; 361(2): 303-311, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28289077