Detalhe da pesquisa
1.
Discovery of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent and selective heparanase-1 inhibitor utilizing an improved synthetic approach.
Bioorg Med Chem Lett
; 97: 129543, 2024 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37939863
2.
Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor.
Bioorg Med Chem Lett
; 79: 129050, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36368497
3.
Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor.
Bioorg Med Chem
; 93: 117460, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37660465
4.
Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-α Stabilization.
Drug Metab Dispos
; 49(1): 20-30, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33087449
5.
TP0463518 (TS-143) Ameliorates Peptidoglycan-Polysaccharide Induced Anemia of Inflammation in Rats.
Biol Pharm Bull
; 44(11): 1653-1661, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34719642
6.
A Diarylacetonitrile as a Molecular Probe for the Detection of Polymeric Mechanoradicals in the Bulk State through a Radical Chain-Transfer Mechanism.
Angew Chem Int Ed Engl
; 60(5): 2680-2683, 2021 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33085132
7.
DMOG, a Prolyl Hydroxylase Inhibitor, Increases Hemoglobin Levels without Exacerbating Hypertension and Renal Injury in Salt-Sensitive Hypertensive Rats.
J Pharmacol Exp Ther
; 372(2): 166-174, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31801803
8.
TP0463518, a Novel Prolyl Hydroxylase Inhibitor, Specifically Induces Erythropoietin Production in the Liver.
J Pharmacol Exp Ther
; 371(3): 675-683, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31585986
9.
Novel Compound Induces Erythropoietin Secretion through Liver Effects in Chronic Kidney Disease Patients and Healthy Volunteers.
Am J Nephrol
; 48(3): 157-164, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30176654
10.
Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia.
Bioorg Med Chem Lett
; 28(10): 1725-1730, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29681433
11.
Adaptive t-vMF dice loss: An effective expansion of dice loss for medical image segmentation.
Comput Biol Med
; 168: 107695, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38061152
12.
Automatic enhancement preprocessing for segmentation of low quality cell images.
Sci Rep
; 14(1): 3619, 2024 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38351053
13.
Expanded tube attention for tubular structure segmentation.
Int J Comput Assist Radiol Surg
; 2023 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38112883
14.
Testing the power-law hypothesis of the interconflict interval.
Sci Rep
; 13(1): 22686, 2023 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38114563
15.
Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.
Biochem J
; 438(1): 111-9, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21605082
16.
Classification and visual explanation for COVID-19 pneumonia from CT images using triple learning.
Sci Rep
; 12(1): 20840, 2022 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36460708
17.
Visualization of the Necking Initiation and Propagation Processes during Uniaxial Tensile Deformation of Crystalline Polymer Films via the Generation of Fluorescent Radicals.
ACS Macro Lett
; 10(5): 623-627, 2021 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35570755
18.
Non-symmetric mechanophores prepared from radical-type symmetric mechanophores: bespoke mechanofunctional polymers.
Chem Commun (Camb)
; 57(23): 2899-2902, 2021 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33616134
19.
Crystallization-induced mechanofluorescence for visualization of polymer crystallization.
Nat Commun
; 12(1): 126, 2021 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33402691
20.
Comparison of dimension reduction methods on fatty acids food source study.
Sci Rep
; 11(1): 18748, 2021 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548525