Detalhe da pesquisa
1.
Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans.
Drug Metab Dispos
; 50(5): 576-590, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35153195
2.
Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes.
J Pharmacol Exp Ther
; 370(1): 72-83, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30975793
3.
Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1.
Drug Metab Dispos
; 47(5): 493-503, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30862625
4.
Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs.
J Pharmacol Exp Ther
; 367(2): 322-334, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30135178
5.
Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein.
Drug Metab Dispos
; 46(8): 1200-1211, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29739809
6.
Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio.
Drug Metab Dispos
; 46(2): 89-99, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29150544
7.
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects.
Drug Metab Dispos
; 46(4): 357-366, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330219
8.
Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation.
Drug Metab Dispos
; 46(5): 692-696, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29439128
9.
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.
Drug Metab Dispos
; 46(4): 346-356, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330218
10.
Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes.
Mol Pharm
; 15(8): 3227-3235, 2018 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29906129
11.
In vitro studies with two human organic anion transporters: OAT2 and OAT7.
Xenobiotica
; 48(10): 1037-1049, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28945155
12.
Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.
Angew Chem Int Ed Engl
; 56(51): 16218-16222, 2017 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29073340
13.
Mechanistic Modeling to Predict Midazolam Metabolite Exposure from In Vitro Data.
Drug Metab Dispos
; 44(5): 781-91, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26956641
14.
Quantitative Rationalization of Gemfibrozil Drug Interactions: Consideration of Transporters-Enzyme Interplay and the Role of Circulating Metabolite Gemfibrozil 1-O-ß-Glucuronide.
Drug Metab Dispos
; 43(7): 1108-18, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25941268
15.
Hepatic Disposition of Gemfibrozil and Its Major Metabolite Gemfibrozil 1-O-ß-Glucuronide.
Mol Pharm
; 12(11): 3943-52, 2015 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26378985
16.
Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of organic anion-transporting polypeptide 1B1 substrates using a mechanistic net-effect model.
J Pharmacol Exp Ther
; 351(1): 214-23, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25107633
17.
Physiologically based pharmacokinetic prediction of telmisartan in human.
Drug Metab Dispos
; 42(10): 1646-55, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25092714
18.
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
J Med Chem
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38687966
19.
Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide.
Pharm Res
; 30(4): 1188-99, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23307347
20.
Quantitative assessment of the contribution of sodium-dependent taurocholate co-transporting polypeptide (NTCP) to the hepatic uptake of rosuvastatin, pitavastatin and fluvastatin.
Biopharm Drug Dispos
; 34(8): 452-61, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23996477