Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Mapping atopic dermatitis and anti-IL-22 response signatures to type 2-low severe neutrophilic asthma.

Badi, Yusef Eamon; Pavel, Ana B; Pavlidis, Stelios; Riley, John H; Bates, Stewart; Kermani, Nazanin Zounemat; Knowles, Richard; Kolmert, Johan; Wheelock, Craig E; Worsley, Sally; Uddin, Mohib; Alving, Kjell; Bakke, Per S; Behndig, Annelie; Caruso, Massimo; Chanez, Pascal; Fleming, Louise J; Fowler, Stephen J; Frey, Urs; Howarth, Peter; Horváth, Ildikó; Krug, Norbert; Maitland-van der Zee, Anke H; Montuschi, Paolo; Roberts, Graham; Sanak, Marek; Shaw, Dominick E; Singer, Florian; Sterk, Peter J; Djukanovic, Ratko; Dahlen, Sven-Eric; Guo, Yi-Ke; Chung, Kian Fan; Guttman-Yassky, Emma; Adcock, Ian M.

J Allergy Clin Immunol ; 149(1): 89-101, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-33891981

2.

Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation.

Sparreman Mikus, Maria; Kolmert, Johan; Andersson, Lars I; Östling, Jörgen; Knowles, Richard G; Gómez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Emami Khoonsari, Payam; Dahlén, Barbro; Kupczyk, Maciej; De Meulder, Bertrand; Auffray, Charles; Bakke, Per S; Beghe, Bianca; Bel, Elisabeth H; Caruso, Massimo; Chanez, Pascal; Chawes, Bo; Fowler, Stephen J; Gaga, Mina; Geiser, Thomas; Gjomarkaj, Mark; Horváth, Ildikó; Howarth, Peter H; Johnston, Sebastian L; Joos, Guy; Krug, Norbert; Montuschi, Paolo; Musial, Jacek; Nizankowska-Mogilnicka, Ewa; Olsson, Henric K; Papi, Alberto; Rabe, Klaus F; Sandström, Thomas; Shaw, Dominick E; Siafakas, Nikolaos M; Uhlén, Mathias; Riley, John H; Bates, Stewart; Middelveld, Roelinde J M; Wheelock, Craig E; Chung, Kian Fan; Adcock, Ian M; Sterk, Peter J; Djukanovic, Ratko; Nilsson, Peter; Dahlén, Sven-Erik; James, Anna.

Eur Respir J ; 59(2)2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34737220

3.

Urinary Leukotriene E₄ and Prostaglandin D₂ Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study.

Kolmert, Johan; Gómez, Cristina; Balgoma, David; Sjödin, Marcus; Bood, Johan; Konradsen, Jon R; Ericsson, Magnus; Thörngren, John-Olof; James, Anna; Mikus, Maria; Sousa, Ana R; Riley, John H; Bates, Stewart; Bakke, Per S; Pandis, Ioannis; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J; Geiser, Thomas; Howarth, Peter; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Behndig, Annelie; Shaw, Dominick E; Knowles, Richard G; Holweg, Cécile T J; Wheelock, Åsa M; Dahlén, Barbro; Nordlund, Björn; Alving, Kjell; Hedlin, Gunilla; Chung, Kian Fan; Adcock, Ian M; Sterk, Peter J; Djukanovic, Ratko; Dahlén, Sven-Erik; Wheelock, Craig E.

Am J Respir Crit Care Med ; 203(1): 37-53, 2021 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-32667261

4.

Nitric Oxide Synthase Inhibitors into the Clinic at Last.

Dao, Vu Thao-Vi; Elbatreek, Mahmoud H; Fuchß, Thomas; Grädler, Ulrich; Schmidt, Harald H H W; Shah, Ajay M; Wallace, Alan; Knowles, Richard.

Handb Exp Pharmacol ; 264: 169-204, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-32797331

5.

Exhaled volatile organic compounds as markers for medication use in asthma.

Brinkman, Paul; Ahmed, Waqar M; Gómez, Cristina; Knobel, Hugo H; Weda, Hans; Vink, Teunis J; Nijsen, Tamara M; Wheelock, Craig E; Dahlen, Sven-Erik; Montuschi, Paolo; Knowles, Richard G; Vijverberg, Susanne J; Maitland-van der Zee, Anke H; Sterk, Peter J; Fowler, Stephen J.

Eur Respir J ; 55(2)2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31515400

6.

"T2-high" in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin.

Pavlidis, Stelios; Takahashi, Kentaro; Ng Kee Kwong, Francois; Xie, Jiaxing; Hoda, Uruj; Sun, Kai; Elyasigomari, Vahid; Agapow, Paul; Loza, Matthew; Baribaud, Fred; Chanez, Pascal; Fowler, Steve J; Shaw, Dominic E; Fleming, Louise J; Howarth, Peter H; Sousa, Ana R; Corfield, Julie; Auffray, Charles; De Meulder, Bertrand; Knowles, Richard; Sterk, Peter J; Guo, Yike; Adcock, Ian M; Djukanovic, Ratko; Fan Chung, Kian.

Eur Respir J ; 53(1)2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30578390

7.

AsthmaMap: An interactive knowledge repository for mechanisms of asthma.

Mazein, Alexander; Ivanova, Olga; Balaur, Irina; Ostaszewski, Marek; Berzhitskaya, Valeriya; Serebriyskaya, Tatiana; Ligon, Thomas; Hasenauer, Jan; De Meulder, Bertrand; Overall, Rupert W; Roy, Ludovic; Knowles, Richard G; Wheelock, Craig E; Dahlen, Sven-Erik; Chung, Kian Fan; Adcock, Ian M; Roberts, Graham; Djukanovic, Ratko; Pellet, Johann; Gawron, Piotr; Balling, Rudi; Maitland-van der Zee, Anke H; Schneider, Reinhard; Sterk, Peter J; Auffray, Charles.

J Allergy Clin Immunol ; 147(3): 853-856, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33309742

8.

Translational models of lung disease.

Mercer, Paul F; Abbott-Banner, Katharine; Adcock, Ian M; Knowles, Richard G.

Clin Sci (Lond) ; 128(4): 235-56, 2015 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-25328010

9.

In vitro pharmacological characterization of vilanterol, a novel long-acting ß2-adrenoceptor agonist with 24-hour duration of action.

Slack, Robert J; Barrett, Victoria J; Morrison, Valerie S; Sturton, Richard G; Emmons, Amanda J; Ford, Alison J; Knowles, Richard G.

J Pharmacol Exp Ther ; 344(1): 218-30, 2013 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-23131596

10.

AsthmaMap: An expert-driven computational representation of disease mechanisms.

Mazein, Alexander; Knowles, Richard G; Adcock, Ian; Chung, Kian Fan; Wheelock, Craig E; Maitland-van der Zee, Anke H; Sterk, Peter J; Auffray, Charles.

Clin Exp Allergy ; 48(8): 916-918, 2018 08.

Artigo em Inglês | MEDLINE | ID: mdl-30133857

11.

Longitudinal characterization of a model of chronic allergic lung inflammation in mice using imaging, functional and immunological methods.

Changani, Kumar; Pereira, Catherine; Young, Simon; Shaw, Robert; Campbell, Simon P; Pindoria, Kashmira; Jordan, Steve; Wiley, Katherine; Bolton, Sarah; Nials, Tony; Haase, Michael; Pedrick, Mike; Knowles, Richard.

Clin Sci (Lond) ; 125(12): 555-64, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-23725401

12.

The risk of chronic psychedelic and MDMA microdosing for valvular heart disease.

Tagen, Michael; Mantuani, Daniel; van Heerden, Liron; Holstein, Alex; Klumpers, Linda E; Knowles, Richard.

J Psychopharmacol ; 37(9): 876-890, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37572027

13.

Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids.

Yasinska, Valentyna; Gómez, Cristina; Kolmert, Johan; Ericsson, Magnus; Pohanka, Anton; James, Anna; Andersson, Lars I; Sparreman-Mikus, Maria; Sousa, Ana R; Riley, John H; Bates, Stewart; Bakke, Per S; Zounemat Kermani, Nazanin; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J; Geiser, Thomas; Howarth, Peter H; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Behndig, Annelie; Shaw, Dominick E; Knowles, Richard G; Dahlén, Barbro; Maitland-van der Zee, Anke-Hilse; Sterk, Peter J; Djukanovic, Ratko; Adcock, Ian M; Chung, Kian Fan; Wheelock, Craig E; Dahlén, Sven-Erik; Wikström Jonsson, Eva.

ERJ Open Res ; 9(5)2023 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-37868143

14.

A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma.

Evans, Rhys L; Nials, Anthony T; Knowles, Richard G; Kidd, Emma J; Ford, William R; Broadley, Kenneth J.

Pulm Pharmacol Ther ; 25(6): 453-64, 2012 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-23046662

15.

In vivo characterization of GSK256066, a high-affinity inhaled phosphodiesterase 4 inhibitor.

Nials, Anthony T; Tralau-Stewart, Cathy J; Gascoigne, Michele H; Ball, Douglas I; Ranshaw, Lisa E; Knowles, Richard G.

J Pharmacol Exp Ther ; 337(1): 137-44, 2011 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-21205924

16.

GSK256066, an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 suitable for administration by inhalation: in vitro, kinetic, and in vivo characterization.

Tralau-Stewart, Cathy J; Williamson, Richard A; Nials, Anthony T; Gascoigne, Michele; Dawson, John; Hart, Graham J; Angell, Anthony D R; Solanke, Yemisi E; Lucas, Fiona S; Wiseman, Joanne; Ward, Peter; Ranshaw, Lisa E; Knowles, Richard G.

J Pharmacol Exp Ther ; 337(1): 145-54, 2011 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-21205923

17.

Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.

Young, Robert J; Alderton, Wendy; Angell, Anthony D R; Beswick, Paul J; Brown, David; Chambers, C Lynn; Crowe, Miriam C; Dawson, John; Hamlett, Christopher C F; Hodgson, Simon T; Kleanthous, Savvas; Knowles, Richard G; Russell, Linda J; Stocker, Richard; Woolven, James M.

Bioorg Med Chem Lett ; 21(10): 3037-40, 2011 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-21482467

18.

Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort.

Alahmadi, Fahad H; Simpson, Andrew J; Gomez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Wheelock, Craig E; Shaw, Dominic E; Fleming, Louise J; Roberts, Graham; Riley, John; Bates, Stewart; Sousa, Ana R; Knowles, Richard; Bansal, Aruna T; Corfield, Julie; Pandis, Ioannis; Sun, Kai; Bakke, Per S; Caruso, Massimo; Chanez, Pascal; Dahlén, Barbro; Horvath, Ildiko; Krug, Norbert; Montuschi, Paolo; Singer, Florian; Wagers, Scott; Adcock, Ian M; Djukanovic, Ratko; Chung, Kian Fan; Sterk, Peter J; Dahlen, Sven-Erik; Fowler, Stephen J.

Chest ; 160(1): 53-64, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-33610577

19.

The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity.

Davis, T Gregg; Peterson, John J; Kou, Jen-Pyng; Capper-Spudich, Elizabeth A; Ball, Doug; Nials, Anthony T; Wiseman, Joanne; Solanke, Yemisi E; Lucas, Fiona S; Williamson, Richard A; Ferrari, Livia; Wren, Paul; Knowles, Richard G; Barnette, Mary S; Podolin, Patricia L.

J Pharmacol Exp Ther ; 330(3): 922-31, 2009 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-19498103

20.

60 seconds with Richard Knowles.

Knowles, Richard.

Nurs Times ; 110(10): 26, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-24741883

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