Detalhe da pesquisa
1.
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.
Nature
; 622(7984): 850-862, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37794185
2.
DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease.
Genes Dev
; 32(13-14): 944-952, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945887
3.
A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models.
J Biol Chem
; 293(5): 1517-1525, 2018 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29217773
4.
A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells.
J Biol Chem
; 290(15): 9646-59, 2015 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25681440
5.
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.
Nat Chem Biol
; 10(7): 558-66, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24845231
6.
Evidence for hysteretic substrate channeling in the proline dehydrogenase and Δ1-pyrroline-5-carboxylate dehydrogenase coupled reaction of proline utilization A (PutA).
J Biol Chem
; 289(6): 3639-51, 2014 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24352662
7.
Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum.
Proc Natl Acad Sci U S A
; 107(7): 2878-83, 2010 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20133651
8.
Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep
; 12(1): 14561, 2022 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36028520
9.
Small Molecule Phenotypic Screen Identifies Novel Regulators of LDLR Expression.
ACS Chem Biol
; 15(12): 3262-3274, 2020 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33270420
10.
Characterization of a Helicobacter hepaticus putA mutant strain in host colonization and oxidative stress.
Infect Immun
; 76(7): 3037-44, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18458068
11.
Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress.
Free Radic Biol Med
; 44(4): 671-81, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18036351
12.
Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development.
Nat Commun
; 9(1): 283, 2018 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29348454
13.
Anxious moments for the protein tyrosine phosphatase PTP1B.
Trends Neurosci
; 38(8): 462-5, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26166619
14.
PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.
J Clin Invest
; 125(8): 3163-77, 2015 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26214522
15.
Reactivation of oxidized PTP1B and PTEN by thioredoxin 1.
FEBS J
; 281(16): 3545-58, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24976139
16.
The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases.
FEBS J
; 280(12): 2830-41, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23578302
17.
H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.
Sci Signal
; 4(203): ra86, 2011 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22169477
18.
Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent.
J Biol Chem
; 284(24): 16066-16070, 2009 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19351884
19.
Structure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilus.
J Biol Chem
; 282(19): 14316-27, 2007 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17344208
20.
Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans.
Infect Immun
; 75(4): 1609-18, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17283095