Detalhe da pesquisa
1.
Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets.
Proc Natl Acad Sci U S A
; 119(24): e2120083119, 2022 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35666870
2.
C4b-binding Protein Protects ß-Cells from Islet Amyloid Polypeptide-induced Cytotoxicity.
J Biol Chem
; 291(41): 21644-21655, 2016 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27566545
3.
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.
Proc Natl Acad Sci U S A
; 111(38): 13924-9, 2014 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25201977
4.
Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets.
J Clin Invest
; 133(4)2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36656641
5.
A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic ß-cells.
Nat Commun
; 13(1): 4237, 2022 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35869052
6.
Islet Gene View-a tool to facilitate islet research.
Life Sci Alliance
; 5(12)2022 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35948367
7.
Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.
Biochem J
; 429(1): 205-13, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20415663
8.
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.
Nat Commun
; 11(1): 4912, 2020 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32999275
9.
Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans.
Cell Rep
; 26(11): 3027-3036.e3, 2019 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30865891
10.
Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents ß Cell Death via ATG16L1 Interaction and Autophagy Regulation.
Cell Metab
; 29(1): 202-210.e6, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30293775
11.
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
Nat Genet
; 51(11): 1596-1606, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31676859
12.
Glucose-Induced Changes in Gene Expression in Human Pancreatic Islets: Causes or Consequences of Chronic Hyperglycemia.
Diabetes
; 66(12): 3013-3028, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28882899
13.
Genetic determinants of circulating GIP and GLP-1 concentrations.
JCI Insight
; 2(21)2017 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29093273
14.
The complement inhibitor CD59 regulates insulin secretion by modulating exocytotic events.
Cell Metab
; 19(5): 883-90, 2014 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24726385
15.
Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and ß-cell function and insulin action in humans.
Diabetes
; 62(8): 2978-83, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23557703
16.
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
Cell Metab
; 16(1): 122-34, 2012 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22768844
17.
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
Cell Metab
; 16(5): 625-33, 2012 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23140642
18.
Abnormal peripheral chemokine profile in Huntington's disease.
PLoS Curr
; 3: RRN1231, 2011 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21826115