Detalhe da pesquisa
1.
HIF-PHD inhibitor desidustat ameliorates iron deficiency anemia.
Toxicol Appl Pharmacol
; 483: 116832, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38266872
2.
Microsomal triglyceride transfer protein inhibitor lomitapide-induced liver toxicity is ameliorated by Triiodothyronine treatment following improved bile homeostasis and ß-oxidation.
Toxicol Appl Pharmacol
; 434: 115825, 2022 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34902352
3.
Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B0AT1 (SLC6A19).
Bioorg Med Chem Lett
; 53: 128421, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34718128
4.
Prolyl hydroxylase inhibitor desidustat protects against acute and chronic kidney injury by reducing inflammatory cytokines and oxidative stress.
Drug Dev Res
; 82(6): 852-860, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33480036
5.
Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates nonalcoholic fatty liver disease.
Can J Physiol Pharmacol
; 96(6): 587-596, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29406832
6.
Influence of acute and chronic kidney failure in rats on the disposition and pharmacokinetics of ZYAN1, a novel prolyl hydroxylase inhibitor, for the treatment of chronic kidney disease-induced anemia.
Xenobiotica
; 48(1): 37-44, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-28042744
7.
Central GLP-1 receptor activation improves cholesterol metabolism partially independent of its effect on food intake.
Can J Physiol Pharmacol
; 94(2): 161-167, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26629909
8.
Cannabinoid receptor 1 antagonist treatment induces glucagon release and shows an additive therapeutic effect with GLP-1 agonist in diet-induced obese mice.
Can J Physiol Pharmacol
; 92(12): 975-83, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25361428
9.
Co-agonist of glucagon and GLP-1 reduces cholesterol and improves insulin sensitivity independent of its effect on appetite and body weight in diet-induced obese C57 mice.
Can J Physiol Pharmacol
; 91(12): 1009-15, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24289070
10.
Long-acting peptidomimetics based DPP-IV inhibitors.
Bioorg Med Chem Lett
; 22(10): 3516-21, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22503246
11.
Inhibition of 11ß-hydroxysteroid dehydrogenase 1 by carbenoxolone affects glucose homeostasis and obesity in db/db mice.
Clin Exp Pharmacol Physiol
; 39(1): 69-77, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22060140
12.
In vivo antidiabetic activity of nimesulide due to inhibition of amino acid transport.
Basic Clin Pharmacol Toxicol
; 130(1): 35-43, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-34634192
13.
Prolyl hydroxylase inhibitor desidustat improves anemia in erythropoietin hyporesponsive state.
Curr Res Pharmacol Drug Discov
; 3: 100102, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35570856
14.
Inhibition of microsomal triglyceride transfer protein improves insulin sensitivity and reduces atherogenic risk in Zucker fatty rats.
Clin Exp Pharmacol Physiol
; 38(5): 338-44, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21401695
15.
Hepcidin inhibition improves iron homeostasis in ferrous sulfate and LPS treatment model in mice.
Drug Res (Stuttg)
; 71(9): 528-534, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34311475
16.
Effect of dual PPAR-α/γ agonist saroglitazar on diabetic retinopathy and oxygen-induced retinopathy.
Eur J Pharmacol
; 899: 174032, 2021 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753107
17.
Combination of Lorcaserin and GLP-1/glucagon Coagonist Improves Metabolic Dysfunction in Diet Induced-obese Mice.
Drug Res (Stuttg)
; 70(8): 376-384, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-32645724
18.
Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a CB1 receptor antagonist with in vivo antiobesity effect.
Bioorg Med Chem Lett
; 19(9): 2546-50, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19328683
19.
Pharmacological inhibition of prolyl hydroxylase protects against inflammation-induced anemia via efficient erythropoiesis and hepcidin downregulation.
Eur J Pharmacol
; 843: 113-120, 2019 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30458168
20.
Activation of GLP-1 and Glucagon Receptors Regulates Bile Homeostasis Independent of Thyroid Hormone.
Curr Mol Pharmacol
; 12(2): 139-146, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30747091