Detalhe da pesquisa
1.
Convergent Syntheses of Isomeric Imidazolospiroketones as Templates for Acetyl-CoA Carboxylase (ACC) Inhibitors.
J Org Chem
; 88(19): 13727-13740, 2023 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37751412
2.
The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems.
J Org Chem
; 81(9): 3509-19, 2016 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27056793
3.
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg Med Chem Lett
; 25(22): 5352-6, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26411795
4.
From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.
Bioorg Med Chem Lett
; 23(1): 194-7, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23177788
5.
Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor.
Bioorg Med Chem Lett
; 23(19): 5410-4, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23953189
6.
Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss.
J Med Chem
; 66(5): 3195-3211, 2023 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36802610
7.
Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.
J Org Chem
; 77(3): 1497-506, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22239115
8.
Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes.
Bioorg Med Chem Lett
; 22(17): 5721-6, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858141
9.
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.
Bioorg Med Chem Lett
; 22(13): 4281-7, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22677316
10.
Synthesis of Deuterated Heterocycles with Me2NCD(OMe)2 and Evaluation of the Products for Metabolism by Aldehyde Oxidase.
ACS Med Chem Lett
; 13(2): 250-256, 2022 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35178182
11.
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
J Med Chem
; 65(22): 15000-15013, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36322383
12.
Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.
Bioorg Med Chem Lett
; 19(12): 3253-8, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19428251
13.
Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.
Bioorg Med Chem Lett
; 18(23): 6071-7, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18951788
14.
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(16): 7273-7288, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30036059
15.
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(6): 2372-2383, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29466005
16.
Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry.
ACS Cent Sci
; 3(2): 101-109, 2017 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28280776
17.
Correction to "Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry".
ACS Cent Sci
; 3(4): 359, 2017 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28470054
18.
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
J Med Chem
; 59(17): 8068-81, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27490827
19.
Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.
J Med Chem
; 58(21): 8513-28, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26509551
20.
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).
J Med Chem
; 58(18): 7173-85, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26349027