Detalhe da pesquisa
1.
HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production.
J Pharmacol Exp Ther
; 364(3): 377-389, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29298820
2.
TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats.
Pharmacol Biochem Behav
; 211: 173289, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34655652
3.
Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington's Disease PSC-Derived Striatal Neurons.
Front Cell Neurosci
; 15: 742763, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34658796
4.
Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.
Sci Rep
; 11(1): 14532, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34267258
5.
Electrophysiological characterization of a novel AMPA receptor potentiator, TAK-137, in rat hippocampal neurons.
Neurosci Lett
; 712: 134488, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31518676
6.
TAK-137, an AMPA receptor potentiator with little agonistic effect, produces antidepressant-like effect without causing psychotomimetic effects in rats.
Pharmacol Biochem Behav
; 183: 80-86, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31202810
7.
Preclinical characterization of AMPA receptor potentiator TAK-137 as a therapeutic drug for schizophrenia.
Pharmacol Res Perspect
; 7(3): e00479, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31086673
8.
TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology
; 44(5): 961-970, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30209408
9.
Author Correction: Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.
Sci Rep
; 11(1): 15255, 2021 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34290388
10.
Possible involvement of a cyclic AMP-dependent mechanism in PACAP-induced proliferation and ERK activation in astrocytes.
Biochem Biophys Res Commun
; 311(2): 337-43, 2003 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-14592419