Detalhe da pesquisa
1.
Enzymatic basis of the Fc-selective intra-chain disulfide reduction and free thiol content variability in an antibody produced in Escherichia coli.
Microb Cell Fact
; 21(1): 167, 2022 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35986313
2.
Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid.
Biotechnol Bioeng
; 112(4): 734-42, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25384896
3.
Utilizing targeted integration CHO pools to potentially accelerate the GMP manufacturing of monoclonal and bispecific antibodies.
Biotechnol Prog
; 40(1): e3399, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-37874920
4.
Eliminating tyrosine sequence variants in CHO cell lines producing recombinant monoclonal antibodies.
Biotechnol Bioeng
; 110(4): 1087-97, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23108857
5.
Bax and Bak knockout apoptosis-resistant Chinese hamster ovary cell lines significantly improve culture viability and titer in intensified fed-batch culture process.
Biotechnol Prog
; 38(2): e3228, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34951158
6.
Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase-mediated cassette exchange system.
Biotechnol Prog
; 37(4): e3140, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33666334
7.
Mechanism of antibody reduction in cell culture production processes.
Biotechnol Bioeng
; 107(4): 622-32, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20589844
8.
Identification and prevention of antibody disulfide bond reduction during cell culture manufacturing.
Biotechnol Bioeng
; 106(3): 452-61, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20178122
9.
Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese Hamster Ovary (CHO) cells.
Biotechnol Bioeng
; 107(1): 163-71, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20506532
10.
High-yield expression of human vascular endothelial growth factor VEGF(165) in Escherichia coli and purification for therapeutic applications.
Protein Expr Purif
; 72(2): 184-93, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20302942
11.
Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position.
Biotechnol Prog
; 36(4): e2967, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31965756
12.
Advancing Biologics Development Programs with Legacy Cell Lines: Advantages and Limitations of Genetic Testing for Addressing Clonality Concerns Prior to Availability of Late Stage Process and Product Consistency Data.
PDA J Pharm Sci Technol
; 74(2): 264-274, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31519780
13.
Pyruvate Kinase Muscle-1 Expression Appears to Drive Lactogenic Behavior in CHO Cell Lines, Triggering Lower Viability and Productivity: A Case Study.
Biotechnol J
; 14(4): e1800332, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30179303
14.
Strain engineering to reduce acetate accumulation during microaerobic growth conditions in Escherichia coli.
Biotechnol Prog
; 34(2): 303-314, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29193870
15.
Development and characterization of an automated imaging workflow to generate clonally-derived cell lines for therapeutic proteins.
Biotechnol Prog
; 34(3): 584-592, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28960825
16.
Beating the odds: The poisson distribution of all input cells during limiting dilution grossly underestimates whether a cell line is clonally-derived or not.
Biotechnol Prog
; 34(3): 559-569, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28941017
17.
Implementation of Plate Imaging for Demonstration of Monoclonality in Biologics Manufacturing Development.
PDA J Pharm Sci Technol
; 72(4): 438-450, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29669815
18.
Evaluation of heavy chain C-terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells.
Biotechnol Prog
; 33(3): 786-794, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28188688
19.
A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies.
Biotechnol Prog
; 33(6): 1449-1455, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28371489
20.
Development of an edema factor-mediated cAMP-induction bioassay for detecting antibody-mediated neutralization of anthrax protective antigen.
J Immunol Methods
; 298(1-2): 47-60, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15847796