Detalhe da pesquisa
1.
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bioorg Med Chem Lett
; 29(16): 2294-2301, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31307887
2.
Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
J Med Chem
; 67(5): 3287-3306, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38431835
3.
Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2).
ACS Med Chem Lett
; 14(9): 1179-1187, 2023 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37736184
4.
Asymmetric total synthesis of (+)-virosine A via sequential nucleophilic cyclizations onto an activated formamide.
J Org Chem
; 77(7): 3215-21, 2012 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22390172
5.
Ate complexes of secondary boronic esters as chiral organometallic-type nucleophiles for asymmetric synthesis.
J Am Chem Soc
; 133(42): 16794-7, 2011 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21939203
6.
A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists.
ACS Med Chem Lett
; 12(8): 1230-1237, 2021 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34413952
7.
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
J Med Chem
; 64(7): 3843-3869, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33749283
8.
Enantioselective construction of quaternary stereogenic centers from tertiary boronic esters: methodology and applications.
Angew Chem Int Ed Engl
; 50(16): 3760-3, 2011 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21374774
9.
Addition of tethered nonaromatic carbon nucleophiles to chemoselectively activated amides.
Org Lett
; 7(20): 4431-4, 2005 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16178551
10.
Rapid assembly of quinolizidines via consecutive nucleophilic cyclizations onto activated amides.
Org Lett
; 13(16): 4268-71, 2011 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21755913
11.
Use of alkyl 2,4,6-triisopropylbenzoates in the asymmetric homologation of challenging boronic esters.
Chem Commun (Camb)
; 47(47): 12592-4, 2011 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21892499
12.
Synthesis of the tricyclic core of alkaloid securinol B using a cascade of Vilsmeier-Haack and Mannich cyclizations.
Org Lett
; 10(20): 4501-4, 2008 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-18816119
13.
Intramolecular additions of various pi-nucleophiles to chemoselectively activated amides and application to the synthesis of (+/-)-tashiromine.
J Org Chem
; 71(2): 704-12, 2006 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16408983