Detalhe da pesquisa
1.
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.
Cell
; 156(3): 563-76, 2014 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24440334
2.
Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore.
Bioorg Med Chem Lett
; 46: 128171, 2021 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34098081
3.
A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the µ-Opioid Receptor.
Mol Pharmacol
; 97(6): 392-401, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32234810
4.
Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence.
Nat Chem Biol
; 13(2): 218-225, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27992879
5.
Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes.
Bioorg Med Chem Lett
; 29(2): 148-154, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30528696
6.
Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes.
J Labelled Comp Radiopharm
; 62(5): 202-208, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30828860
7.
Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5.
Mol Pharmacol
; 93(5): 477-488, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29476042
8.
Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors.
Bioorg Med Chem Lett
; 28(9): 1507-1515, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29627263
9.
Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability.
Bioorg Med Chem Lett
; 28(10): 1972-1980, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29650289
10.
In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis.
J Nanobiotechnology
; 16(1): 97, 2018 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30482196
11.
Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol Pharmacol
; 92(6): 707-717, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29070696
12.
Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma.
Bioorg Med Chem Lett
; 27(8): 1744-1749, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28285914
13.
Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.
J Biol Chem
; 290(34): 20649-20659, 2015 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26032411
14.
Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis.
Am J Pathol
; 185(4): 969-86, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25681733
15.
Blockade of the renin-angiotensin system prevents acute and immunologically relevant colitis in murine models.
Pediatr Surg Int
; 32(12): 1103-1114, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27670279
16.
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.
J Virol
; 88(20): 11825-33, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25100850
17.
Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo.
J Virol
; 88(19): 11199-214, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25031353
18.
Discovery of anthranilamides as a novel class of inhibitors of neurotropic alphavirus replication.
Bioorg Med Chem
; 23(7): 1569-87, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25740634
19.
Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice.
Proc Natl Acad Sci U S A
; 109(9): 3469-74, 2012 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22331877
20.
The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases.
J Lipid Res
; 55(7): 1215-25, 2014 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24534703