Detalhe da pesquisa
1.
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
Cell
; 145(6): 863-74, 2011 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21640374
2.
Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
J Biol Chem
; 289(16): 10975-10987, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24596089
3.
Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).
Bioorg Med Chem Lett
; 25(23): 5555-60, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522950
4.
Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists.
Bioorg Med Chem Lett
; 22(20): 6454-9, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22963764
5.
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities.
Expert Opin Drug Deliv
; 19(10): 1265-1283, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35877189
6.
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious ß-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease.
J Med Chem
; 64(20): 15262-15279, 2021 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34648711
7.
Synthesis of the Potent, Selective, and Efficacious ß-Secretase (BACE1) Inhibitor NB-360.
J Med Chem
; 64(8): 4677-4696, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33844524
8.
Structure determination of neoefrapeptins A to N: peptides with insecticidal activity produced by the fungus Geotrichum candidum.
J Antibiot (Tokyo)
; 59(5): 267-80, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16883776
9.
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-ß and neuroinflammation in APP transgenic mice.
Mol Neurodegener
; 10: 44, 2015 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26336937
10.
Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.
J Med Chem
; 56(19): 7590-607, 2013 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23964859
11.
Distinct effects of IPSU and suvorexant on mouse sleep architecture.
Front Neurosci
; 7: 235, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24368893
12.
Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors.
Front Neurosci
; 7: 230, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24376396
13.
Plant-plant signaling: application of trans- or cis-methyl jasmonate equivalent to sagebrush releases does not elicit direct defenses in native tobacco.
J Chem Ecol
; 30(11): 2193-214, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15672665