Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Phase I/II study of the pharmacokinetics, safety and antiretroviral activity of tenofovir alafenamide, a new prodrug of the HIV reverse transcriptase inhibitor tenofovir, in HIV-infected adults.

Markowitz, Martin; Zolopa, Andrew; Squires, Kathleen; Ruane, Peter; Coakley, Dion; Kearney, Brian; Zhong, Lijie; Wulfsohn, Michael; Miller, Michael D; Lee, William A.

J Antimicrob Chemother ; 69(5): 1362-9, 2014 May.

Artigo em Inglês | MEDLINE | ID: mdl-24508897

2.

Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340.

Babusis, Darius; Phan, Truc K; Lee, William A; Watkins, William J; Ray, Adrian S.

Mol Pharm ; 10(2): 459-66, 2013 Feb 04.

Artigo em Inglês | MEDLINE | ID: mdl-22738467

3.

Natural substrate concentrations can modulate the prophylactic efficacy of nucleotide HIV reverse transcriptase inhibitors.

García-Lerma, J Gerardo; Aung, Wutyi; Cong, Mian-er; Zheng, Qi; Youngpairoj, Ae S; Mitchell, James; Holder, Angela; Martin, Amy; Kuklenyik, Susan; Luo, Wei; Lin, Carol Yen-Chin; Hanson, Debra L; Kersh, Ellen; Pau, Chou-Pong; Ray, Adrian S; Rooney, James F; Lee, William A; Heneine, Walid.

J Virol ; 85(13): 6610-7, 2011 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-21525346

4.

Tenofovir alafenamide fumarate.

Lee, William A; Cheng, Andrew K.

Antivir Ther ; 27(2): 13596535211067600, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35499175

5.

Targeting lipid biosynthesis pathways for hepatitis B virus cure.

Hyrina, Anastasia; Burdette, Dara; Song, Zhijuan; Ramirez, Ricardo; Okesli-Armlovich, Ayse; Vijayakumar, Archana; Bates, Jamie; Trevaskis, James L; Fletcher, Simon P; Lee, William A; Holdorf, Meghan M.

PLoS One ; 17(8): e0270273, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35925919

6.

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection.

Vermillion, Meghan S; Murakami, Eisuke; Ma, Bin; Pitts, Jared; Tomkinson, Adrian; Rautiola, Davin; Babusis, Darius; Irshad, Hammad; Seigel, Dustin; Kim, Cynthia; Zhao, Xiaofeng; Niu, Congrong; Yang, Jesse; Gigliotti, Andrew; Kadrichu, Nani; Bilello, John P; Ellis, Scott; Bannister, Roy; Subramanian, Raju; Smith, Bill; Mackman, Richard L; Lee, William A; Kuehl, Philip J; Hartke, Jim; Cihlar, Tomas; Porter, Danielle P.

Sci Transl Med ; 14(633): eabl8282, 2022 Feb 23.

Artigo em Inglês | MEDLINE | ID: mdl-34968150

7.

Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase.

Shih, I-Hung; Vliegen, Inge; Peng, Betty; Yang, Huiling; Hebner, Christy; Paeshuyse, Jan; Pürstinger, Gerhard; Fenaux, Martijn; Tian, Yang; Mabery, Eric; Qi, Xiaoping; Bahador, Gina; Paulson, Matthew; Lehman, Laura S; Bondy, Steven; Tse, Winston; Reiser, Hans; Lee, William A; Schmitz, Uli; Neyts, Johan; Zhong, Weidong.

Antimicrob Agents Chemother ; 55(9): 4196-203, 2011 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-21746939

8.

Substituted imidazopyridines as potent inhibitors of HCV replication.

Vliegen, Inge; Paeshuyse, Jan; De Burghgraeve, Tine; Lehman, Laura S; Paulson, Matthew; Shih, I-Hung; Mabery, Eric; Boddeker, Nina; De Clercq, Erik; Reiser, Hans; Oare, David; Lee, William A; Zhong, Weidong; Bondy, Steven; Pürstinger, Gerhard; Neyts, Johan.

J Hepatol ; 50(5): 999-1009, 2009 May.

Artigo em Inglês | MEDLINE | ID: mdl-19303654

9.

GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.

Wolfgang, Grushenka H I; Shibata, Riri; Wang, Jianying; Ray, Adrian S; Wu, Sylvia; Doerrfler, Edward; Reiser, Hans; Lee, William A; Birkus, Gabriel; Christensen, Neil D; Andrei, Graciela; Snoeck, Robert.

Antimicrob Agents Chemother ; 53(7): 2777-84, 2009 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-19398642

10.

GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma.

Reiser, Hans; Wang, Jianying; Chong, Lee; Watkins, William J; Ray, Adrian S; Shibata, Riri; Birkus, Gabriel; Cihlar, Tomas; Wu, Sylvia; Li, Bei; Liu, Xiaohong; Henne, Ilana N; Wolfgang, Grushenka H I; Desai, Manoj; Rhodes, Gerald R; Fridland, Arnold; Lee, William A; Plunkett, William; Vail, David; Thamm, Douglas H; Jeraj, Robert; Tumas, Daniel B.

Clin Cancer Res ; 14(9): 2824-32, 2008 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-18451250

11.

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy.

Lim, So-Yon; Osuna, Christa E; Hraber, Peter T; Hesselgesser, Joe; Gerold, Jeffrey M; Barnes, Tiffany L; Sanisetty, Srisowmya; Seaman, Michael S; Lewis, Mark G; Geleziunas, Romas; Miller, Michael D; Cihlar, Tomas; Lee, William A; Hill, Alison L; Whitney, James B.

Sci Transl Med ; 10(439)2018 05 02.

Artigo em Inglês | MEDLINE | ID: mdl-29720451

12.

Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.

Cihlar, Tomas; He, Gong-Xin; Liu, Xiaohong; Chen, James M; Hatada, Marcos; Swaminathan, Swami; McDermott, Martin J; Yang, Zheng-Yu; Mulato, Andrew S; Chen, Xiaowu; Leavitt, Stephanie A; Stray, Kirsten M; Lee, William A.

J Mol Biol ; 363(3): 635-47, 2006 Oct 27.

Artigo em Inglês | MEDLINE | ID: mdl-16979654

13.

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.

Siegel, Dustin; Hui, Hon C; Doerffler, Edward; Clarke, Michael O; Chun, Kwon; Zhang, Lijun; Neville, Sean; Carra, Ernest; Lew, Willard; Ross, Bruce; Wang, Queenie; Wolfe, Lydia; Jordan, Robert; Soloveva, Veronica; Knox, John; Perry, Jason; Perron, Michel; Stray, Kirsten M; Barauskas, Ona; Feng, Joy Y; Xu, Yili; Lee, Gary; Rheingold, Arnold L; Ray, Adrian S; Bannister, Roy; Strickley, Robert; Swaminathan, Swami; Lee, William A; Bavari, Sina; Cihlar, Tomas; Lo, Michael K; Warren, Travis K; Mackman, Richard L.

J Med Chem ; 60(5): 1648-1661, 2017 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-28124907

14.

Perspectives on the development of acyclic nucleotide analogs as antiviral drugs.

Lee, William A; Martin, John C.

Antiviral Res ; 71(2-3): 254-9, 2006 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-16837073

15.

Nucleotide analogue prodrug tenofovir disoproxil enhances lymphoid cell loading following oral administration in monkeys.

Durand-Gasselin, Lucie; Van Rompay, Koen K A; Vela, Jennifer E; Henne, Ilana N; Lee, William A; Rhodes, Gerry R; Ray, Adrian S.

Mol Pharm ; 6(4): 1145-51, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19545170

16.

Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus.

Van Rompay, Koen K A; Kearney, Brian P; Sexton, Jonathan J; Colón, Roxana; Lawson, Jonathan R; Blackwood, Emily J; Lee, William A; Bischofberger, Norbert; Marthas, Marta L.

J Acquir Immune Defic Syndr ; 43(1): 6-14, 2006 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-16810108

17.

Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.

Watkins, William J; Chen, James M; Cho, Aesop; Chong, Lee; Collins, Nicole; Fardis, Maria; Huang, Wei; Hung, Magdeleine; Kirschberg, Thorsten; Lee, William A; Liu, Xiaohong; Thomas, William; Xu, Jie; Zeynalzadegan, Ameneh; Zhang, Jennifer.

Bioorg Med Chem Lett ; 16(13): 3479-83, 2006 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-16621550

18.

Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.

Lee, William A; He, Gong-Xin; Eisenberg, Eugene; Cihlar, Tomas; Swaminathan, Swami; Mulato, Andrew; Cundy, Kenneth C.

Antimicrob Agents Chemother ; 49(5): 1898-906, 2005 May.

Artigo em Inglês | MEDLINE | ID: mdl-15855512

19.

Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.

Keith, Kathy A; Hitchcock, Michael J M; Lee, William A; Holý, Antonin; Kern, Earl R.

Antimicrob Agents Chemother ; 47(7): 2193-8, 2003 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-12821467

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