Detalhe da pesquisa
1.
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
J Pharmacol Exp Ther
; 328(1): 131-40, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18854490
2.
Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.
J Med Chem
; 49(21): 6147-50, 2006 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17034118
3.
Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
J Alzheimers Dis
; 7(2): 139-48; discussion 173-80, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15851852
4.
Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).
J Med Chem
; 47(26): 6447-50, 2004 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15588077
5.
CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity.
Org Lett
; 5(14): 2473-5, 2003 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12841758
6.
Increased muscle force production and bone mineral density in ActRIIB-Fc-treated mature rodents.
J Gerontol A Biol Sci Med Sci
; 68(10): 1181-92, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23525481
7.
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.
PLoS One
; 5(2): e9094, 2010 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20161710
8.
BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres.
Bioorg Med Chem Lett
; 16(14): 3635-8, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16690314
9.
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane.
Bioorg Med Chem Lett
; 15(4): 977-82, 2005 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15686896
10.
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Bioorg Med Chem Lett
; 15(8): 2129-34, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15808483
11.
Biochemical and cell-based assays for characterization of BACE-1 inhibitors.
Anal Biochem
; 342(1): 144-51, 2005 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15958191
12.
Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.
J Biol Chem
; 280(18): 17792-7, 2005 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15737955
13.
Altering expression levels of human immunodeficiency virus type 1 gp120-gp41 affects efficiency but not kinetics of cell-cell fusion.
J Virol
; 76(7): 3522-33, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11884576
14.
Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells.
J Virol
; 77(19): 10645-50, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12970449
15.
Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail.
J Virol
; 78(7): 3429-35, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15016865
16.
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.
Bioorg Med Chem Lett
; 14(4): 935-9, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15012997
17.
Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor.
Bioorg Med Chem Lett
; 14(13): 3419-24, 2004 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15177445
18.
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity.
Bioorg Med Chem Lett
; 12(20): 2997-3000, 2002 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12270192
19.
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
Bioorg Med Chem Lett
; 12(4): 677-9, 2002 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11844699
20.
1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains.
Bioorg Med Chem Lett
; 13(3): 427-31, 2003 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12565944