Detalhe da pesquisa
1.
Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics.
Anal Chem
; 95(49): 17957-17961, 2023 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38084380
2.
Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry.
Anal Chem
; 95(11): 4834-4839, 2023 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36876898
3.
High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry.
Proc Natl Acad Sci U S A
; 117(18): 9851-9856, 2020 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32327606
4.
Using a peptide-based mass spectrometry approach to quantitate proteolysis of an intact heterogeneous procollagen substrate by BMP1 for antagonistic antibody screening.
Anal Bioanal Chem
; 414(22): 6601-6610, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35821276
5.
Characterizing and Quantitating Therapeutic Tethered Multimeric Antibody Degradation Using Affinity Capture Mass Spectrometry.
Anal Chem
; 92(10): 6839-6843, 2020 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32309925
6.
Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry.
Anal Chem
; 92(2): 2186-2193, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31880920
7.
Quantitative Determination of Protein-Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry.
Anal Chem
; 91(1): 903-911, 2019 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30481450
8.
Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates.
Drug Metab Dispos
; 47(10): 1156-1163, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31085544
9.
High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers.
Bioconjug Chem
; 29(2): 473-485, 2018 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29425028
10.
Modulating Antibody-Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification.
Bioconjug Chem
; 29(4): 1155-1167, 2018 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29481745
11.
An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.
Nat Chem Biol
; 12(7): 531-8, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27214401
12.
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.
Nature
; 488(7409): 96-9, 2012 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22801501
13.
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.
Bioorg Med Chem Lett
; 27(13): 2974-2981, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28512031
14.
Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening.
J Neurosci
; 35(7): 2927-41, 2015 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25698732
15.
Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies.
Anal Chem
; 88(23): 11521-11526, 2016 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27797494
16.
Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies.
Bioorg Med Chem Lett
; 26(16): 4036-41, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27406798
17.
Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.
Bioorg Med Chem Lett
; 26(18): 4492-4496, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27499454
18.
Identification of potent, selective KDM5 inhibitors.
Bioorg Med Chem Lett
; 26(17): 4350-4, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27476424
19.
Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein.
J Biol Chem
; 289(45): 30990-1000, 2014 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25253696
20.
Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase.
Chembiochem
; 15(8): 1121-30, 2014 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24797455