Detalhe da pesquisa
1.
Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells.
Arch Toxicol
; 97(4): 1113-1131, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36864359
2.
Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4).
Arch Toxicol
; 97(3): 685-696, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36436016
3.
Bioassay-directed analysis-based identification of relevant pyrrolizidine alkaloids.
Arch Toxicol
; 96(8): 2299-2317, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35610518
4.
Perfluoroalkyl substances (PFASs) decrease the expression of recombination-activating genes (RAG1 and RAG2) in human B lymphoma Namalwa cells.
Arch Toxicol
; 2022 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36326898
5.
Development of a Web-Based Toolbox to Support Quantitative In-Vitro-to-In-Vivo Extrapolations (QIVIVE) within Nonanimal Testing Strategies.
Chem Res Toxicol
; 34(2): 460-472, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33382582
6.
Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?
Crit Rev Toxicol
; 51(2): 141-164, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33853480
7.
Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry.
Arch Toxicol
; 95(4): 1287-1301, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33651127
8.
Cytochrome P450 expression, induction and activity in human induced pluripotent stem cell-derived intestinal organoids and comparison with primary human intestinal epithelial cells and Caco-2 cells.
Arch Toxicol
; 95(3): 907-922, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33263786
9.
Estrogen receptor alpha (ERα)-mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17ß-estradiol (E2).
Cell Biol Toxicol
; 36(5): 417-435, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32088792
10.
Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells.
Arch Toxicol
; 94(9): 3137-3155, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32588087
11.
Defining in vivo dose-response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach.
J Appl Toxicol
; 40(12): 1647-1660, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33034907
12.
Use of an in vitro-in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine.
Arch Toxicol
; 93(3): 801-818, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30661089
13.
The in vivo developmental toxicity of diethylstilbestrol (DES) in rat evaluated by an alternative testing strategy.
Arch Toxicol
; 93(7): 2021-2033, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31119342
14.
The effects of all-trans retinoic acid on estrogen receptor signaling in the estrogen-sensitive MCF/BUS subline.
J Recept Signal Transduct Res
; 38(2): 112-121, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29447503
15.
Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data.
Arch Toxicol
; 92(3): 1075-1088, 2018 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-29234833
16.
Characterization of the differential coregulator binding signatures of the Retinoic Acid Receptor subtypes upon (ant)agonist action.
Biochim Biophys Acta Proteins Proteom
; 1865(9): 1195-1206, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28642153
17.
Use of Physiologically Based Kinetic Modeling-Based Reverse Dosimetry to Predict in Vivo Toxicity from in Vitro Data.
Chem Res Toxicol
; 30(1): 114-125, 2017 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27768849
18.
Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling.
Arch Toxicol
; 91(9): 3093-3108, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28357488
19.
Risk assessment for pyrrolizidine alkaloids detected in (herbal) teas and plant food supplements.
Regul Toxicol Pharmacol
; 86: 292-302, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28347763
20.
Extended evaluation on the ES-D3 cell differentiation assay combined with the BeWo transport model, to predict relative developmental toxicity of triazole compounds.
Arch Toxicol
; 90(5): 1225-37, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26047666