Detalhe da pesquisa
1.
Smarca2 genetic ablation is phenotypically benign in a safety assessment of tamoxifen-inducible conditional knockout rats.
Toxicol Appl Pharmacol
; 475: 116627, 2023 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37453479
2.
Establishment of baseline profiles of 50 bile acids in preclinical toxicity species: A comprehensive assessment of translational differences and study design considerations for biomarker development.
Toxicol Appl Pharmacol
; 443: 116008, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35378153
3.
Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFß pathway inhibition.
Toxicol Appl Pharmacol
; 438: 115905, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35122773
4.
Polysorbate 80-Induced Anaphylactoid Reaction and the Effects on Cardiovascular Function: Dose Threshold and Species Comparison.
Int J Toxicol
; 41(2): 99-107, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35245984
5.
Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs.
Toxicol Pathol
; 48(3): 465-480, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32124659
6.
In vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk.
Arch Toxicol
; 94(9): 3185-3200, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32583097
7.
Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition.
Toxicol Appl Pharmacol
; 338: 204-213, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29146462
8.
Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making.
Chem Res Toxicol
; 29(4): 452-72, 2016 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26625186
9.
Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene.
Drug Metab Dispos
; 43(1): 93-9, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25349122
10.
Circulating microRNA 122 in the methionine and choline-deficient mouse model of non-alcoholic steatohepatitis.
J Appl Toxicol
; 34(6): 726-32, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24217942
11.
Using Genetically Modified Rodent Models in Drug Development to Explore Target Physiology and Potential Drug Effects.
Vet Pathol
; 55(2): 193-194, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29457566
12.
Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.
Arch Biochem Biophys
; 508(1): 101-9, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21303654
13.
Cardiovascular microphysiological systems (CVMPS) for safety studies - a pharma perspective.
Lab Chip
; 21(3): 458-472, 2021 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33471007
14.
Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.
J Med Chem
; 64(6): 2953-2966, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33682420
15.
Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung.
Carcinogenesis
; 31(10): 1833-43, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20513672
16.
The rise of antioxidant signaling--the evolution and hormetic actions of Nrf2.
Toxicol Appl Pharmacol
; 244(1): 4-15, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20122947
17.
Atypical presentation and pathogenesis of a macaque lymphocryptoviral-associated B-cell lymphoma in a cynomolgus monkey.
Vet Clin Pathol
; 49(1): 130-136, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-32009251
18.
RIP1 kinase activity is critical for skin inflammation but not for viral propagation.
J Leukoc Biol
; 107(6): 941-952, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31985117
19.
Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity.
ACS Med Chem Lett
; 11(3): 327-333, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184965
20.
Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems.
Biochem Biophys Res Commun
; 389(3): 431-6, 2009 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19732748