Detalhe da pesquisa
1.
Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL-286, a novel retinoic acid receptor-ß agonist for treatment of spinal cord injury, in male healthy participants.
Br J Clin Pharmacol
; 89(12): 3573-3583, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37452623
2.
Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy.
N Engl J Med
; 377(9): 819-828, 2017 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28691885
3.
Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvß6 inhibitor, in healthy participants.
Eur J Clin Pharmacol
; 74(6): 701-709, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29532104
4.
Pegylated, full-length, recombinant factor VIII for prophylactic and on-demand treatment of severe hemophilia A.
Blood
; 126(9): 1078-85, 2015 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26157075
5.
Comparison of the pharmacokinetics, safety, and immunogenicity of MSB11022, a biosimilar of adalimumab, with Humira(®) in healthy subjects.
Br J Clin Pharmacol
; 82(4): 983-93, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27285856
6.
Is there a role of synovial biopsy in drug development?
BMC Musculoskelet Disord
; 17: 172, 2016 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27094362
7.
The effects of house dust mite sublingual immunotherapy tablet on immunologic biomarkers and nasal allergen challenge symptoms.
J Allergy Clin Immunol
; 141(2): 785-788.e9, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28911971
8.
Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies.
Br J Clin Pharmacol
; 76(1): 78-88, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23190017
9.
Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran-Results of the phase 1 inhibitor cohort.
J Thromb Haemost
; 19(6): 1436-1446, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33587824
10.
Pharmacokinetic equivalence, comparable safety, and immunogenicity of an adalimumab biosimilar product (M923) to Humira in healthy subjects.
Pharmacol Res Perspect
; 6(1)2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29417761
11.
Effect of oral posaconazole on the pharmacokinetics of cyclosporine and tacrolimus.
Pharmacotherapy
; 27(6): 825-34, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17542765
12.
Polypharmacy and Unplanned Hospitalizations in Patients with Rheumatoid Arthritis.
J Rheumatol
; 44(12): 1786-1793, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28966210
13.
PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers.
J Clin Pharmacol
; 57(2): 194-210, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27406873
14.
Investigation of Potential Pharmacodynamic and Pharmacokinetic Interactions Between Selexipag and Warfarin in Healthy Male Subjects.
Clin Ther
; 38(5): 1228-1236.e1, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27063071
15.
Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies.
Drugs R D
; 16(1): 81-92, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26739683
16.
Pharmacokinetics and Tolerability of the Novel Oral Prostacyclin IP Receptor Agonist Selexipag.
Am J Cardiovasc Drugs
; 15(3): 195-203, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25850750
17.
Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies.
Clin Ther
; 37(12): 2811-22, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26514315
18.
Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects.
Arthritis Res Ther
; 17: 282, 2015 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26449617
19.
Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection.
Drugs R D
; 12(3): 127-39, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22852579
20.
DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial.
Vaccine
; 27(18): 2506-12, 2009 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19368793