Detalhe da pesquisa
1.
Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O6-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O6-Alkylguanine Adductome.
Chem Res Toxicol
; 36(12): 1921-1929, 2023 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37983188
2.
The DNA Alkyltransferase Family of DNA Repair Proteins: Common Mechanisms, Diverse Functions.
Int J Mol Sci
; 25(1)2023 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38203633
3.
O6-methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function.
Proc Natl Acad Sci U S A
; 115(18): 4731-4736, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29666243
4.
Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.
Mol Cell
; 47(1): 50-60, 2012 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22658721
5.
Flipping of alkylated DNA damage bridges base and nucleotide excision repair.
Nature
; 459(7248): 808-13, 2009 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19516334
6.
Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations.
Nucleic Acids Res
; 41(10): 5524-32, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23580550
7.
The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase.
Nucleic Acids Res
; 41(5): 3047-55, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23335782
8.
Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions.
Proc Natl Acad Sci U S A
; 109(46): 18755-60, 2012 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23112169
9.
O6-carboxymethylguanine in DNA forms a sequence context-dependent wobble base-pair structure with thymine.
Acta Crystallogr D Biol Crystallogr
; 70(Pt 6): 1669-79, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24914978
10.
Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells.
Mol Cancer
; 13: 154, 2014 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24941944
11.
Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus.
Nucleic Acids Res
; 40(16): 7806-20, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22669901
12.
Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis.
Mutat Res Genet Toxicol Environ Mutagen
; 758(1-2): 80-6, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24140386
13.
QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency.
Pharmaceutics
; 15(8)2023 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37631385
14.
Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria.
Am J Pathol
; 178(4): 1715-27, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21435453
15.
Towards more specific O6-methylguanine-DNA methyltransferase (MGMT) inactivators.
Bioorg Med Chem
; 19(5): 1658-65, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21320783
16.
Targeting O6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy.
Cell Mol Life Sci
; 67(21): 3663-81, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20717836
17.
Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of O6-methylguanine and their recognition by MGMT and Atl1.
Nucleosides Nucleotides Nucleic Acids
; 39(8): 1108-1121, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32449465
18.
GSTM1 copy number and lung cancer risk.
Mutat Res
; 664(1-2): 1-5, 2009 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19428374
19.
Lung cancer risk and variation in MGMT activity and sequence.
DNA Repair (Amst)
; 6(8): 1134-44, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17569600
20.
Alkyltransferase-like proteins.
DNA Repair (Amst)
; 6(8): 1222-8, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17500045