Detalhe da pesquisa
1.
A paracrine requirement for hedgehog signalling in cancer.
Nature
; 455(7211): 406-10, 2008 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-18754008
2.
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.
N Engl J Med
; 361(12): 1164-72, 2009 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19726763
3.
Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling.
Drug Metab Dispos
; 38(7): 1029-38, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20406853
4.
Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway.
Bioorg Med Chem Lett
; 20(22): 6748-53, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20875741
5.
GDC-0449-a potent inhibitor of the hedgehog pathway.
Bioorg Med Chem Lett
; 19(19): 5576-81, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19716296
6.
Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.
Protein Sci
; 15(2): 290-303, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16384997
7.
A structure-based database of antibody variable domain diversity.
J Mol Biol
; 348(3): 699-709, 2005 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15826665
8.
Contributions of CDR3 to V H H domain stability and the design of monobody scaffolds for naive antibody libraries.
J Mol Biol
; 332(3): 643-55, 2003 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12963373
9.
Discovery and preclinical development of vismodegib.
Expert Opin Drug Discov
; 9(8): 969-84, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24857041
10.
Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened.
Clin Cancer Res
; 17(10): 3378-87, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21558397
11.
CDK2/cyclinA inhibitors: targeting the cyclinA recruitment site with small molecules derived from peptide leads.
Bioorg Med Chem Lett
; 16(6): 1716-20, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16384702
12.
Selective detection of membrane proteins without antibodies: a mass spectrometric version of the Western blot.
Mol Cell Proteomics
; 1(2): 148-56, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12096133
13.
N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.
Bioorg Med Chem Lett
; 13(6): 1015-8, 2003 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12643901
14.
N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety.
Bioorg Med Chem Lett
; 14(9): 2055-9, 2004 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15080978
15.
VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism.
Nature
; 417(6892): 954-8, 2002 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12087404
16.
Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
Bioorg Med Chem Lett
; 12(20): 2913-7, 2002 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12270174