Detalhe da pesquisa
1.
Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers.
Mol Cell
; 84(10): 1964-1979.e6, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38759628
2.
Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma.
Br J Cancer
; 127(5): 937-947, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35618788
3.
Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy.
Blood
; 126(2): 222-32, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26031918
4.
Identification of potent and selective MTH1 inhibitors.
Bioorg Med Chem Lett
; 26(6): 1503-1507, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26898335
5.
Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types.
Clin Cancer Res
; 30(10): 2121-2139, 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38416404
6.
Comparative Pharmacology of a Bis-Pivaloyloxymethyl Phosphonate Prodrug Inhibitor of Enolase after Oral and Parenteral Administration.
ACS Pharmacol Transl Sci
; 6(2): 245-252, 2023 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36798479
7.
Subtype and Site Specific-Induced Metabolic Vulnerabilities in Prostate Cancer.
Mol Cancer Res
; 21(1): 51-61, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36112348
8.
Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance.
bioRxiv
; 2023 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36747713
9.
Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis.
Nat Commun
; 14(1): 2194, 2023 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37069167
10.
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials.
Nat Med
; 29(1): 115-126, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36658425
11.
Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma.
Mol Oncol
; 16(5): 1132-1152, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34632715
12.
PGC1α/ß Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer.
Cancer Res
; 82(7): 1423-1434, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35131872
13.
Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.
Nat Commun
; 13(1): 2801, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35589701
14.
The Combined Treatment With the FLT3-Inhibitor AC220 and the Complex I Inhibitor IACS-010759 Synergistically Depletes Wt- and FLT3-Mutated Acute Myeloid Leukemia Cells.
Front Oncol
; 11: 686765, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34490088
15.
Cork-in-bottle mechanism of inhibitor binding to mammalian complex I.
Sci Adv
; 7(20)2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33990335
16.
Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLL.
Blood Adv
; 5(16): 3134-3146, 2021 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34424317
17.
Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition.
Blood Adv
; 5(20): 4233-4255, 2021 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34507353
18.
Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.
J Med Chem
; 64(20): 15141-15169, 2021 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34643390
19.
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J Med Chem
; 64(15): 11302-11329, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292726
20.
Short-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in Braf-mutated melanoma.
Oncoimmunology
; 10(1): 1992880, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34777916