Detalhe da pesquisa
1.
Selective Inhibition of the Hsp90α Isoform.
Angew Chem Int Ed Engl
; 60(19): 10547-10551, 2021 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33621416
2.
Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.
Mol Cell
; 47(3): 434-43, 2012 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22727666
3.
Identification of proteins associated with Aha1 in HeLa cells by quantitative proteomics.
Biochim Biophys Acta
; 1854(5): 365-80, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25614414
4.
The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors.
J Proteome Res
; 12(8): 3697-706, 2013 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23763277
5.
Approaches for defining the Hsp90-dependent proteome.
Biochim Biophys Acta
; 1823(3): 656-67, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21906632
6.
Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.
Biochim Biophys Acta
; 1823(6): 1092-101, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22504172
7.
Structural basis of the key residue W320 responsible for Hsp90 conformational change.
J Biomol Struct Dyn
; 41(19): 9745-9755, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36373326
8.
Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur J Med Chem
; 258: 115531, 2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37307624
9.
Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target.
Acta Crystallogr D Struct Biol
; 78(Pt 5): 571-585, 2022 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35503206
10.
Structure-Activity Relationship Study of Tertiary Alcohol Hsp90α-Selective Inhibitors with Novel Binding Mode.
ACS Med Chem Lett
; 13(12): 1870-1878, 2022 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36518703
11.
Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.
BMC Cancer
; 11: 468, 2011 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22039910
12.
Identification and initial SAR of silybin: an Hsp90 inhibitor.
Bioorg Med Chem Lett
; 21(9): 2659-64, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21273068
13.
Direct ribosomal binding by a cellular inhibitor of translation.
Nat Struct Mol Biol
; 13(2): 103-11, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16429152
14.
A systematic protocol for the characterization of Hsp90 modulators.
Bioorg Med Chem
; 19(1): 684-92, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21129982
15.
Gambogic acid, a natural product inhibitor of Hsp90.
J Nat Prod
; 74(5): 1085-92, 2011 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21486005
16.
Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells.
Prostate
; 70(1): 27-36, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19739131
17.
KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells.
Mol Pharmacol
; 76(6): 1314-22, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19741006
18.
Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.
Bioorg Med Chem
; 17(2): 634-40, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19101151
19.
Direct interaction of the cell division cycle 37 homolog inhibits endothelial nitric oxide synthase activity.
Circ Res
; 98(3): 335-41, 2006 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16410463
20.
A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine.
Methods Mol Biol
; 1709: 87-96, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29177653