Detalhe da pesquisa
1.
Recent developments in predicting CYP-independent metabolism.
Drug Metab Rev
; 53(2): 188-206, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33941024
2.
RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature
; 526(7574): 583-6, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26466569
3.
Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Proc Natl Acad Sci U S A
; 110(14): 5689-94, 2013 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23493555
4.
Phase IIa Study of PLX2853 in Gynecologic Cancers With Known ARID1A Mutation and Phase Ib/IIa Study of PLX2853/Carboplatin in Platinum-Resistant Epithelial Ovarian Cancer.
JCO Precis Oncol
; 7: e2300235, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37797273
5.
Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
JAMA Oncol
; 7(9): 1343-1350, 2021 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34236401
6.
PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors.
Clin Exp Med
; 19(2): 201-210, 2019 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-30523507
7.
The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma.
JCI Insight
; 3(14)2018 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046005
8.
BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
Cancer Discov
; 8(4): 458-477, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29386193
9.
Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.
Cancer Discov
; 5(6): 668-79, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25847190
10.
Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.
Neuron
; 82(2): 380-97, 2014 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24742461