Detalhe da pesquisa
1.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 179(2): 417-431.e19, 2019 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31585081
2.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 180(2): 406, 2020 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31978350
3.
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
J Allergy Clin Immunol
; 150(4): 972-978.e7, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35487308
4.
Dual functionality of ß-tryptase protomers as both proteases and cofactors in the active tetramer.
J Biol Chem
; 293(25): 9614-9628, 2018 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29661938
5.
An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.
Nat Chem Biol
; 10(7): 567-73, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24859116
6.
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
Proc Natl Acad Sci U S A
; 110(32): E2987-96, 2013 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23882082
7.
Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.
Sci Transl Med
; 14(675): eabp9159, 2022 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36516271
8.
Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
J Biol Chem
; 285(34): 26570-80, 2010 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20504762
9.
Allosteric peptide activators of pro-hepatocyte growth factor stimulate Met signaling.
J Biol Chem
; 285(51): 40362-72, 2010 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20937841
10.
Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer.
Biol Chem
; 391(8): 881-92, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20536384
11.
Development of a specific immunoassay to selectively measure active tryptase in airway samples.
Bioanalysis
; 12(19): 1377-1388, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32975431
12.
Bivalent antibody pliers inhibit ß-tryptase by an allosteric mechanism dependent on the IgG hinge.
Nat Commun
; 11(1): 6435, 2020 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33353951
13.
Suppressor of fused regulates Gli activity through a dual binding mechanism.
Mol Cell Biol
; 24(19): 8627-41, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15367681
14.
Disulfide locked variants of factor VIIa with a restricted beta-strand conformation have enhanced enzymatic activity.
Protein Sci
; 14(5): 1171-80, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15840825
15.
Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.
PLoS One
; 8(12): e83958, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24409221
16.
Efficient production of antibodies against a mammalian integral membrane protein by phage display.
Protein Eng Des Sel
; 24(9): 679-89, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21810920
17.
Crystal structure analysis of free and substrate-bound 6-hydroxy-L-nicotine oxidase from Arthrobacter nicotinovorans.
J Mol Biol
; 396(3): 785-99, 2010 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20006620
18.
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat Struct Mol Biol
; 16(7): 691-7, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19561609
19.
Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist.
Proc Natl Acad Sci U S A
; 104(13): 5306-11, 2007 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17372204
20.
Engineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage.
J Biol Chem
; 278(24): 21823-30, 2003 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12657647