Detalhe da pesquisa
1.
Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.
Biochem J
; 476(18): 2521-2543, 2019 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31409651
2.
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo.
J Med Chem
; 65(12): 8191-8207, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35653645
3.
Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins.
Sci Rep
; 11(1): 10475, 2021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34006961
4.
A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection.
Sci Rep
; 11(1): 10617, 2021 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34012108
5.
Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer.
Oncogene
; 38(25): 5076-5090, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30905967
6.
Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease.
J Med Chem
; 62(5): 2447-2465, 2019 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30779566
7.
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur J Med Chem
; 177: 316-337, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31158747
8.
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep
; 6: 34701, 2016 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27708405
9.
Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Cancer Res
; 75(16): 3340-54, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26202014
10.
Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2.
PLoS One
; 8(6): e65689, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23776527
11.
Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1).
J Med Chem
; 56(24): 10045-65, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24256217
12.
Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit.
J Biomol Screen
; 15(3): 279-86, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20147598