Detalhe da pesquisa
1.
Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes.
J Med Chem
; 66(4): 2622-2645, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36749938
2.
Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases.
Bioorg Med Chem Lett
; 20(14): 4045-9, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20561787
3.
Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease.
J Med Chem
; 62(5): 2447-2465, 2019 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30779566
4.
A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera.
J Mol Biol
; 367(3): 882-94, 2007 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17275837
5.
Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.
J Med Chem
; 51(7): 2147-57, 2008 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18345609
6.
Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.
J Med Chem
; 50(10): 2289-92, 2007 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-17451235
7.
The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma.
Oncotarget
; 7(3): 2329-42, 2016 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26295308
8.
Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).
J Med Chem
; 59(11): 5221-37, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27167172
9.
Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.
Oncotarget
; 6(15): 13019-35, 2015 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25968568
10.
Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors.
J Med Chem
; 55(22): 10229-40, 2012 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23082860
11.
Cancer Drug Discovery 2010: from molecules to medicine.
Expert Rev Clin Pharmacol
; 3(5): 613-5, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22111742
12.
Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt).
J Med Chem
; 53(5): 2239-49, 2010 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20151677
13.
Identification of inhibitors of checkpoint kinase 1 through template screening.
J Med Chem
; 52(15): 4810-9, 2009 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19572549