Detalhe da pesquisa
1.
Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy.
Bioorg Chem
; 131: 106282, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36459777
2.
New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure-activity relationships, and molecular modelling.
J Enzyme Inhib Med Chem
; 36(1): 2025-2044, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34514909
3.
Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line.
J Enzyme Inhib Med Chem
; 36(1): 1029-1047, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34107837
4.
Microtubule Destabilizing Sulfonamides as an Alternative to Taxane-Based Chemotherapy.
Int J Mol Sci
; 22(4)2021 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33673002
5.
Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring.
Bioorg Chem
; 98: 103755, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32200330
6.
Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target.
Med Res Rev
; 39(3): 775-830, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30362234
7.
The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors.
Molecules
; 24(23)2019 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31779228
8.
p,p-Dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin inhibition.
J Org Chem
; 79(15): 6840-57, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24966024
9.
New para-para stilbenophanes: synthesis by McMurry coupling, conformational analysis and inhibition of tubulin polymerisation.
Chemistry
; 17(12): 3406-19, 2011 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21344518
10.
Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents.
Eur J Med Chem
; 209: 112933, 2021 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33328100
11.
New diarylsulfonamide inhibitors of Leishmania infantum amastigotes.
Int J Parasitol Drugs Drug Resist
; 16: 45-64, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34015753
12.
Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds.
Bioorg Med Chem
; 17(17): 6422-31, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19647439
13.
Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.
Bioorg Med Chem
; 16(19): 8999-9008, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18790642
14.
Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization.
Bioorg Med Chem
; 16(11): 5952-61, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18502133
15.
Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells.
Eur J Med Chem
; 158: 167-183, 2018 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30216850
16.
Inhibition of the intestinal absorption of bile acids using cationic derivatives: mechanism and repercussions.
Biochem Pharmacol
; 73(3): 394-404, 2007 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17134679
17.
Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases.
Biochem Pharmacol
; 73(9): 1394-404, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17257589
18.
Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines.
Molecules
; 11(11): 929-39, 2006 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-18007397
19.
Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.
J Med Chem
; 48(2): 556-68, 2005 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-15658869
20.
Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins.
Eur J Med Chem
; 100: 210-22, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26092446