Detalhe da pesquisa
1.
Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators.
ACS Med Chem Lett
; 14(7): 986-992, 2023 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37465306
2.
Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.
ACS Med Chem Lett
; 14(8): 1088-1094, 2023 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37583812
3.
Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology.
J Biol Chem
; 285(22): 17054-64, 2010 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20356837
4.
Discovery of selective glucocorticoid receptor modulator MK-5932.
Bioorg Med Chem
; 19(24): 7374-86, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22079253
5.
Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands.
J Biol Chem
; 284(52): 36367-36376, 2009 Dec 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19846549
6.
Nonpeptide alphavbeta3 antagonists. 8. In vitro and in vivo evaluation of a potent alphavbeta3 antagonist for the prevention and treatment of osteoporosis.
J Med Chem
; 46(22): 4790-8, 2003 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-14561098
7.
Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells.
J Steroid Biochem Mol Biol
; 143: 29-39, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24565564
8.
The preclinical efficacy, selectivity and pharmacologic profile of MK-5932, an insulin-sparing selective glucocorticoid receptor modulator.
Eur J Pharmacol
; 724: 102-11, 2014 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24374007
9.
Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs).
J Med Chem
; 52(15): 4578-81, 2009 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19606870
10.
Nonpeptide alpha(v)beta3 antagonists: identification of potent, chain-shortened 7-oxo RGD mimetics.
Bioorg Med Chem Lett
; 15(6): 1647-50, 2005 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15745815
11.
Non-peptide alpha(v)beta(3) antagonists: identification of potent, chain-shortened RGD mimetics that incorporate a central pyrrolidinone constraint.
Bioorg Med Chem Lett
; 13(24): 4285-8, 2003 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14643310
12.
Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide.
Bioorg Med Chem Lett
; 12(1): 25-9, 2002 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-11738566