Detalhe da pesquisa
1.
A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.
Cell
; 177(4): 1067-1079.e19, 2019 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31051099
2.
Multimodal small-molecule screening for human prion protein binders.
J Biol Chem
; 295(39): 13516-13531, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32723867
3.
A drug discovery toolbox for Nuclear Magnetic Resonance (NMR) characterization of ligands and their targets.
Drug Discov Today Technol
; 37: 51-60, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34895655
4.
The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity.
Biochemistry
; 56(51): 6639-6651, 2017 12 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29185708
5.
Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.
Bioorg Med Chem Lett
; 26(4): 1314-8, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26786695
6.
An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin.
Org Biomol Chem
; 11(28): 4680-5, 2013 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23752953
7.
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules.
Nat Cell Biol
; 24(12): 1766-1775, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36396978
8.
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J Med Chem
; 64(15): 11148-11168, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34342224
9.
Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides.
Biomolecules
; 10(1)2019 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31861275
10.
Determination of the binding mode of thienopyrimidinedione antagonists to the human gonadotropin releasing hormone receptor using structure-activity relationships, site-directed mutagenesis, and homology modeling.
J Med Chem
; 49(21): 6170-6, 2006 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17034124
11.
Targeting Bacterial Cell Wall Peptidoglycan Synthesis by Inhibition of Glycosyltransferase Activity.
Chem Biol Drug Des
; 87(2): 190-9, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26358369
12.
Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design.
ACS Med Chem Lett
; 7(4): 374-8, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096044
13.
Three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) from HIV-1.
J Mol Biol
; 333(2): 409-24, 2003 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-14529626
14.
Structure-Activity Relationship Studies of a Series of Semisynthetic Lipopeptides Leading to the Discovery of Surotomycin, a Novel Cyclic Lipopeptide Being Developed for the Treatment of Clostridium difficile-Associated Diarrhea.
J Med Chem
; 58(12): 5137-42, 2015 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25993059
15.
Dipolar Waves as NMR maps of helices in proteins.
J Magn Reson
; 163(2): 288-99, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12914844
16.
NMR structural characterization of a minimal peptide antagonist bound to the extracellular domain of the corticotropin-releasing factor1 receptor.
J Biol Chem
; 282(9): 6338-46, 2007 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17192263
17.
NMR structure determination of a membrane protein with two transmembrane helices in micelles: MerF of the bacterial mercury detoxification system.
Biochemistry
; 44(13): 5196-206, 2005 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15794657
18.
Atropisomeric property of 1-(2,6-difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil.
Chirality
; 17(9): 559-64, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16196024
19.
Structure and dynamics of a membrane protein in micelles from three solution NMR experiments.
J Biomol NMR
; 26(4): 327-34, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12815259
20.
Structure determination of aligned samples of membrane proteins by NMR spectroscopy.
Magn Reson Chem
; 42(2): 162-71, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14745796