Detalhe da pesquisa
1.
Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation.
Bioorg Med Chem Lett
; 97: 129541, 2024 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37952596
2.
Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor.
Bioorg Med Chem Lett
; 79: 129050, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36368497
3.
Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor.
Bioorg Med Chem
; 93: 117460, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37660465
4.
Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532.
Bioorg Med Chem
; 30: 115964, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33385955
5.
Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors.
Bioorg Med Chem
; 28(22): 115776, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33032189
6.
Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold.
J Med Chem
; 66(1): 822-836, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36595440
7.
Unique structure of ozoralizumab, a trivalent anti-TNFα NANOBODY® compound, offers the potential advantage of mitigating the risk of immune complex-induced inflammation.
Front Immunol
; 14: 1149874, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37122706
8.
Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 65(12): 8493-8510, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35687819
9.
Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation.
ACS Omega
; 5(17): 10145-10159, 2020 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32391502
10.
Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity.
J Med Chem
; 63(23): 14805-14820, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33210531
11.
Crystallization and preliminary X-ray crystallographic analysis of Ca2+-free primary Ca2+-sensor of Na+/Ca2+ exchanger.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 64(Pt 12): 1125-7, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19052365