Detalhe da pesquisa
1.
Single-stranded siRNAs activate RNAi in animals.
Cell
; 150(5): 883-94, 2012 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22939618
2.
Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function.
Nucleic Acids Res
; 44(11): 5299-312, 2016 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27131367
3.
Identification of metabolically stable 5'-phosphate analogs that support single-stranded siRNA activity.
Nucleic Acids Res
; 43(6): 2993-3011, 2015 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25753666
4.
Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.
Bioorg Med Chem Lett
; 26(15): 3690-3, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27268307
5.
Synergistic effect of phosphorothioate, 5'-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA.
Bioorg Med Chem Lett
; 26(12): 2817-2820, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27161280
6.
Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.
Nucleic Acids Res
; 42(22): 13456-68, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25398895
7.
The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials.
Eur Heart J
; 36(24): 1536-46, 2015 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25802390
8.
Efficient Synthesis and Biological Evaluation of 5'-GalNAc Conjugated Antisense Oligonucleotides.
Bioconjug Chem
; 26(8): 1451-5, 2015 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26011654
9.
Effectiveness of a walking programme to support adults with intellectual disabilities to increase physical activity: walk well cluster-randomised controlled trial.
Int J Behav Nutr Phys Act
; 12: 125, 2015 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416606
10.
Identification of metabolically stable 5Î-phosphate analogs that support single-stranded siRNA activity.
Nucleic Acids Res
; 45(11): 6994, 2017 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28472515
11.
Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk.
Arterioscler Thromb Vasc Biol
; 31(10): 2338-44, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21757655
12.
Changes in body weight and food choice in those attempting smoking cessation: a cluster randomised controlled trial.
BMC Public Health
; 12: 389, 2012 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22642755
13.
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials.
Lancet
; 375(9716): 735-42, 2010 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20167359
14.
Fasting plasma glucose in non-diabetic participants and the risk for incident cardiovascular events, diabetes, and mortality: results from WOSCOPS 15-year follow-up.
Eur Heart J
; 31(10): 1230-6, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20395260
15.
Binding and cleavage specificities of human Argonaute2.
J Biol Chem
; 284(38): 26017-28, 2009 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19625255
16.
Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?
PLoS Med
; 6(6): e1000099, 2009 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19554082
17.
Cangrelor versus Ticagrelor in Patients Treated with Primary Percutaneous Coronary Intervention: Impact on Platelet Activity, Myocardial Microvascular Function and Infarct Size: A Randomized Controlled Trial.
Thromb Haemost
; 119(7): 1171-1181, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31129911
18.
C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER).
Circulation
; 115(8): 981-9, 2007 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17283264
19.
Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer.
Sci Rep
; 8(1): 1216, 2018 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29352147
20.
Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver.
Nucleic Acid Ther
; 27(4): 209-220, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28448194