Detalhe da pesquisa
1.
Discovery of quinazoline HPK1 inhibitors with high cellular potency.
Bioorg Med Chem
; 92: 117423, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37531921
2.
Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity.
J Pharmacol Exp Ther
; 376(3): 397-409, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33328334
3.
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.
J Chem Inf Model
; 60(11): 5457-5474, 2020 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32813975
4.
Predicting Residence Time and Drug Unbinding Pathway through Scaled Molecular Dynamics.
J Chem Inf Model
; 59(1): 535-549, 2019 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30500211
5.
Estimation of Protein-Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations.
J Chem Inf Model
; 59(12): 5135-5147, 2019 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31697501
6.
Ligand-Induced Conformational Changes in HSP90 Monitored Time Resolved and Label Free-Towards a Conformational Activity Screening for Drug Discovery.
Angew Chem Int Ed Engl
; 57(31): 9955-9960, 2018 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29772085
7.
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Nat Chem Biol
; 11(12): 973-980, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26502155
8.
Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates.
Bioorg Med Chem Lett
; 27(3): 551-556, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27998678
9.
Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore.
Bioorg Med Chem Lett
; 26(5): 1443-51, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26852363
10.
Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors.
Biochemistry
; 52(4): 613-26, 2013 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23290007
11.
Fragment-based discovery of focal adhesion kinase inhibitors.
Bioorg Med Chem Lett
; 23(19): 5401-9, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23973211
12.
R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis.
Arthritis Rheumatol
; 75(3): 375-386, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36054172
13.
Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression.
ACS Med Chem Lett
; 14(5): 566-576, 2023 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37197456
14.
Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.
J Med Chem
; 66(13): 8666-8686, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37403966
15.
Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11ß-hydroxysteroid dehydrogenase type I.
Bioorg Med Chem Lett
; 22(18): 5909-14, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22901389
16.
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.
Bioorg Med Chem Lett
; 22(13): 4396-403, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22632933
17.
Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106.
J Med Chem
; 65(13): 9206-9229, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35763499
18.
Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (ß5i).
J Med Chem
; 64(14): 10230-10245, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34228444
19.
M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (ß5i) Delivering Efficacy in Multiple Myeloma Models.
Mol Cancer Ther
; 20(8): 1378-1387, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34045234
20.
Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.
J Med Chem
; 64(14): 10371-10392, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34255518