Detalhe da pesquisa
1.
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.
Br J Cancer
; 116(9): 1166-1176, 2017 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28334731
2.
Conformational preferences of oxy-substituents in butenolide-tetrahydropyran spiroacetals and butenolide-piperidine spiro-N,O-acetals.
Org Biomol Chem
; 10(17): 3506-18, 2012 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22430567
3.
Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2.
Bioorg Med Chem
; 18(2): 707-18, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20022510
4.
High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers.
Mol Cancer Ther
; 18(10): 1696-1707, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31575759
5.
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
J Med Chem
; 59(8): 3671-88, 2016 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27055065
6.
Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Cancer Res
; 75(16): 3340-54, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26202014
7.
Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1).
J Med Chem
; 56(24): 10045-65, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24256217
8.
Synthesis of spiroacetal enol ethers by oxidative activation of furan derivatives.
Org Lett
; 10(23): 5445-8, 2008 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18986155