Detalhe da pesquisa
1.
Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Mol Cell
; 83(10): 1725-1742.e12, 2023 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37084731
2.
Assigning functionality to cysteines by base editing of cancer dependency genes.
Nat Chem Biol
; 19(11): 1320-1330, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37783940
3.
Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain.
Proc Natl Acad Sci U S A
; 119(35): e2208457119, 2022 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35994671
4.
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders.
J Am Chem Soc
; 146(15): 10393-10406, 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38569115
5.
Chemical Proteomic Discovery of Isotype-Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2.
Angew Chem Int Ed Engl
; 62(51): e202311924, 2023 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37909922
6.
Small Molecule Modulation of Proteasome Assembly.
Biochemistry
; 57(28): 4214-4224, 2018 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29897236
7.
Redirecting the pioneering function of FOXA1 with covalent small molecules.
bioRxiv
; 2024 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38562719
8.
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly.
ACS Chem Biol
; 19(2): 254-265, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38198472
9.
Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes.
bioRxiv
; 2024 Feb 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38464067
10.
Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators.
ACS Omega
; 8(17): 15650-15659, 2023 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37151549
11.
Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma.
Biomedicines
; 10(5)2022 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35625675
12.
Regulation of Autophagic Flux by the 20S Proteasome.
Cell Chem Biol
; 26(9): 1283-1294.e5, 2019 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31327703
13.
Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders.
J Med Chem
; 62(14): 6469-6481, 2019 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30839208
14.
Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins.
ACS Chem Biol
; 12(9): 2240-2247, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28719185
15.
Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-ß.
Protein Pept Lett
; 22(10): 869-76, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26216267