Detalhe da pesquisa
1.
Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants.
J Biol Chem
; 298(6): 101972, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35461811
2.
Differences in the regulatory strategies of marine oligotrophs and copiotrophs reflect differences in motility.
Environ Microbiol
; 25(7): 1265-1280, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36826469
3.
Acoustic Ejection Mass Spectrometry for High-Throughput Analysis.
Anal Chem
; 93(31): 10850-10861, 2021 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34320311
4.
SAR11 bacteria have a high affinity and multifunctional glycine betaine transporter.
Environ Microbiol
; 21(7): 2559-2575, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31090982
5.
Complete genome sequence of a winter season Vibrio facilitates discovery of a novel subclade of cold-adapted species in the albus clade.
Microb Genom
; 10(1)2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38230915
6.
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
J Med Chem
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38687966
7.
A Reduction of Transcriptional Regulation in Aquatic Oligotrophic Microorganisms Enhances Fitness in Nutrient-Poor Environments.
Microbiol Mol Biol Rev
; 87(2): e0012422, 2023 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36995249
8.
Structural basis of the acyl-transfer mechanism of human GPAT1.
Nat Struct Mol Biol
; 30(1): 22-30, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36522428
9.
Unique Geothermal Chemistry Shapes Microbial Communities on Mt. Erebus, Antarctica.
Front Microbiol
; 13: 836943, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35591982
10.
SAR11 Cells Rely on Enzyme Multifunctionality To Metabolize a Range of Polyamine Compounds.
mBio
; 12(4): e0109121, 2021 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34425701
11.
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Nat Commun
; 12(1): 6055, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34663813
12.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Science
; 374(6575): 1586-1593, 2021 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34726479
13.
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
bioRxiv
; 2021 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32935104
14.
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
J Med Chem
; 63(21): 12725-12747, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33054210
15.
Draft Genome Sequence of Janthinobacterium sp. Strain PC23-8, Isolated from a Freshwater Stream Impacted by Acid Mine Drainage.
Microbiol Resour Announc
; 8(41)2019 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31601663
16.
A Parasitic Arsenic Cycle That Shuttles Energy from Phytoplankton to Heterotrophic Bacterioplankton.
mBio
; 10(2)2019 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30890605
17.
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
J Med Chem
; 61(7): 3008-3026, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29498843
18.
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
J Med Chem
; 60(7): 3094-3108, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28257199
19.
Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates.
PLoS One
; 10(3): e0119141, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25763858
20.
The RESOLUTE consortium: unlocking SLC transporters for drug discovery.
Nat Rev Drug Discov
; 19(7): 429-430, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32265506