Detalhe da pesquisa
1.
Fluoxetine exerts anti-inflammatory effects on human epidermal keratinocytes and suppresses their endothelin release.
Exp Dermatol
; 33(1): e14988, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38284184
2.
Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models.
J Immunol
; 202(10): 2888-2906, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30988116
3.
Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation.
Proc Natl Acad Sci U S A
; 115(7): 1582-1587, 2018 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29382747
4.
Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate.
J Transl Med
; 16(1): 156, 2018 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29879987
5.
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.
Proc Natl Acad Sci U S A
; 112(34): 10768-73, 2015 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26261308
6.
Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.
Nat Chem Biol
; 10(4): 305-12, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24584101
7.
Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.
Int J Mol Sci
; 16(1): 1008-29, 2015 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25569083
8.
A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.
Nat Chem Biol
; 8(6): 576-82, 2012 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22544264
9.
MyMD-1 Improves Health Span and Prolongs Life Span in Old Mice: A Noninferiority Study to Rapamycin.
J Gerontol A Biol Sci Med Sci
; 78(2): 227-235, 2023 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35914953
10.
RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents.
J Pharmacol Exp Ther
; 341(1): 90-103, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22228807
11.
A tubulin binding molecule drives differentiation of acute myeloid leukemia cells.
iScience
; 25(8): 104787, 2022 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35992086
12.
Single-cell, phosphoepitope-specific analysis demonstrates cell type- and pathway-specific dysregulation of Jak/STAT and MAPK signaling associated with in vivo human immunodeficiency virus type 1 infection.
J Virol
; 82(7): 3702-12, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18216116
13.
NF-kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity.
Mol Cell Biol
; 26(19): 7283-98, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16980629
14.
Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures.
PLoS One
; 14(9): e0222944, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31560729
15.
Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.
Cell Chem Biol
; 24(7): 858-869.e5, 2017 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28669525
16.
Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit.
J Med Chem
; 59(10): 4800-11, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27115555
17.
Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.
Cancer Res
; 75(23): 5106-5119, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26552700
18.
Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation.
PLoS One
; 8(3): e58966, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23505568
19.
Differentiation-dependent mechanisms of transcriptional regulation of the catalytic subunit of phosphorylase kinase.
Biochem J
; 362(Pt 1): 199-211, 2002 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11829757
20.
Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65.
J Biol Chem
; 279(18): 18137-45, 2004 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-14963024