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1.

p53: A tale of complexity and context.

Oren, Moshe; Prives, Carol.

Cell ; 187(7): 1569-1573, 2024 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-38552605

2.

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.

Hoshino, Ayuko; Kim, Han Sang; Bojmar, Linda; Gyan, Kofi Ennu; Cioffi, Michele; Hernandez, Jonathan; Zambirinis, Constantinos P; Rodrigues, Gonçalo; Molina, Henrik; Heissel, Søren; Mark, Milica Tesic; Steiner, Loïc; Benito-Martin, Alberto; Lucotti, Serena; Di Giannatale, Angela; Offer, Katharine; Nakajima, Miho; Williams, Caitlin; Nogués, Laura; Pelissier Vatter, Fanny A; Hashimoto, Ayako; Davies, Alexander E; Freitas, Daniela; Kenific, Candia M; Ararso, Yonathan; Buehring, Weston; Lauritzen, Pernille; Ogitani, Yusuke; Sugiura, Kei; Takahashi, Naoko; Aleckovic, Masa; Bailey, Kayleen A; Jolissant, Joshua S; Wang, Huajuan; Harris, Ashton; Schaeffer, L Miles; García-Santos, Guillermo; Posner, Zoe; Balachandran, Vinod P; Khakoo, Yasmin; Raju, G Praveen; Scherz, Avigdor; Sagi, Irit; Scherz-Shouval, Ruth; Yarden, Yosef; Oren, Moshe; Malladi, Mahathi; Petriccione, Mary; De Braganca, Kevin C; Donzelli, Maria.

Cell ; 182(4): 1044-1061.e18, 2020 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-32795414

3.

Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.

Minzel, Waleed; Venkatachalam, Avanthika; Fink, Avner; Hung, Eric; Brachya, Guy; Burstain, Ido; Shaham, Maya; Rivlin, Amitai; Omer, Itay; Zinger, Adar; Elias, Shlomo; Winter, Eitan; Erdman, Paul E; Sullivan, Robert W; Fung, Leah; Mercurio, Frank; Li, Dansu; Vacca, Joseph; Kaushansky, Nathali; Shlush, Liran; Oren, Moshe; Levine, Ross; Pikarsky, Eli; Snir-Alkalay, Irit; Ben-Neriah, Yinon.

Cell ; 175(1): 171-185.e25, 2018 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-30146162

4.

The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.

Kadosh, Eliran; Snir-Alkalay, Irit; Venkatachalam, Avanthika; May, Shahaf; Lasry, Audrey; Elyada, Ela; Zinger, Adar; Shaham, Maya; Vaalani, Gitit; Mernberger, Marco; Stiewe, Thorsten; Pikarsky, Eli; Oren, Moshe; Ben-Neriah, Yinon.

Nature ; 586(7827): 133-138, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32728212

5.

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.

Kotler, Eran; Shani, Odem; Goldfeld, Guy; Lotan-Pompan, Maya; Tarcic, Ohad; Gershoni, Anat; Hopf, Thomas A; Marks, Debora S; Oren, Moshe; Segal, Eran.

Mol Cell ; 71(1): 178-190.e8, 2018 07 05.

Artigo em Inglês | MEDLINE | ID: mdl-29979965

6.

p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells.

Hassin, Ori; Sernik, Miriam; Seligman, Adi; Vogel, Felix C E; Wellenstein, Max D; Smollich, Joachim; Halperin, Coral; Pirona, Anna Chiara; Toledano, Liron Nomi; Caballero, Carolina Dehesa; Schlicker, Lisa; Salame, Tomer-Meir; Sarusi Portuguez, Avital; Aylon, Yael; Scherz-Shouval, Ruth; Geiger, Tamar; de Visser, Karin E; Schulze, Almut; Oren, Moshe.

Proc Natl Acad Sci U S A ; 120(52): e2311460120, 2023 Dec 26.

Artigo em Inglês | MEDLINE | ID: mdl-38127986

7.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

Lü, YiQing; Cho, Tiffany; Mukherjee, Saptaparna; Suarez, Carmen Florencia; Gonzalez-Foutel, Nicolas S; Malik, Ahmad; Martinez, Sebastien; Dervovic, Dzana; Oh, Robin Hyunseo; Langille, Ellen; Al-Zahrani, Khalid N; Hoeg, Lisa; Lin, Zhen Yuan; Tsai, Ricky; Mbamalu, Geraldine; Rotter, Varda; Ashton-Prolla, Patricia; Moffat, Jason; Chemes, Lucia Beatriz; Gingras, Anne-Claude; Oren, Moshe; Durocher, Daniel; Schramek, Daniel.

Mol Syst Biol ; 2024 Apr 05.

Artigo em Inglês | MEDLINE | ID: mdl-38580884

8.

Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins.

Mukherjee, Saptaparna; Maddalena, Martino; Lü, YiQing; Martinez, Sebastien; Nataraj, Nishanth Belugali; Noronha, Ashish; Sinha, Sansrity; Teng, Katie; Cohen-Kaplan, Victoria; Ziv, Tamar; Arandkar, Sharathchandra; Hassin, Ori; Chatterjee, Rishita; Pirona, Anna-Chiara; Shreberk-Shaked, Michal; Gershoni, Anat; Aylon, Yael; Elazar, Zvulun; Yarden, Yosef; Schramek, Daniel; Oren, Moshe.

Proc Natl Acad Sci U S A ; 119(17): e2119644119, 2022 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-35439056

9.

p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity.

Tovy, Ayala; Spiro, Adam; McCarthy, Ryan; Shipony, Zohar; Aylon, Yael; Allton, Kendra; Ainbinder, Elena; Furth, Noa; Tanay, Amos; Barton, Michelle; Oren, Moshe.

Genes Dev ; 31(10): 959-972, 2017 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-28607180

10.

ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP.

Abbas, Ruqaia; Hartmann, Oliver; Asiss, Dorin Theodora; Abbas, Rabab; Kagan, Julia; Kim, Hyoung-Tae; Oren, Moshe; Diefenbacher, Markus; Orian, Amir; Larisch, Sarit.

Apoptosis ; 2024 Apr 29.

Artigo em Inglês | MEDLINE | ID: mdl-38684550

11.

TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment.

Maddalena, Martino; Mallel, Giuseppe; Nataraj, Nishanth Belugali; Shreberk-Shaked, Michal; Hassin, Ori; Mukherjee, Saptaparna; Arandkar, Sharathchandra; Rotkopf, Ron; Kapsack, Abby; Lambiase, Giuseppina; Pellegrino, Bianca; Ben-Isaac, Eyal; Golani, Ofra; Addadi, Yoseph; Hajaj, Emma; Eilam, Raya; Straussman, Ravid; Yarden, Yosef; Lotem, Michal; Oren, Moshe.

Proc Natl Acad Sci U S A ; 118(23)2021 06 08.

Artigo em Inglês | MEDLINE | ID: mdl-34088837

12.

The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.

Aylon, Yael; Gershoni, Anat; Rotkopf, Ron; Biton, Inbal E; Porat, Ziv; Koh, Anna P; Sun, Xiaochen; Lee, Youngmin; Fiel, Maria-Isabel; Hoshida, Yujin; Friedman, Scott L; Johnson, Randy L; Oren, Moshe.

Genes Dev ; 30(7): 786-97, 2016 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-27013235

13.

Down-regulation of LATS kinases alters p53 to promote cell migration.

Furth, Noa; Bossel Ben-Moshe, Noa; Pozniak, Yair; Porat, Ziv; Geiger, Tamar; Domany, Eytan; Aylon, Yael; Oren, Moshe.

Genes Dev ; 29(22): 2325-30, 2015 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-26588988

14.

Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia.

Tuval, Amos; Brilon, Yardena; Azogy, Hadas; Moskovitz, Yoni; Leshkowitz, Dena; Salame, Tomer M; Minden, Mark D; Tal, Perry; Rotter, Varda; Oren, Moshe; Kaushansky, Nathali; Shlush, Liran I.

Haematologica ; 107(11): 2548-2561, 2022 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-35199506

15.

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.

Kotler, Eran; Shani, Odem; Goldfeld, Guy; Lotan-Pompan, Maya; Tarcic, Ohad; Gershoni, Anat; Hopf, Thomas A; Marks, Debora S; Oren, Moshe; Segal, Eran.

Mol Cell ; 71(5): 873, 2018 09 06.

Artigo em Inglês | MEDLINE | ID: mdl-30193102

16.

Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features.

Arandkar, Sharathchandra; Furth, Noa; Elisha, Yair; Nataraj, Nishanth Belugali; van der Kuip, Heiko; Yarden, Yosef; Aulitzky, Walter; Ulitsky, Igor; Geiger, Benjamin; Oren, Moshe.

Proc Natl Acad Sci U S A ; 115(25): 6410-6415, 2018 06 19.

Artigo em Inglês | MEDLINE | ID: mdl-29866855

17.

Corrigendum: p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity.

Tovy, Ayala; Spiro, Adam; McCarthy, Ryan; Shipony, Zohar; Aylon, Yael; Allton, Kendra; Ainbinder, Elena; Furth, Noa; Tanay, Amos; Barton, Michelle; Oren, Moshe.

Genes Dev ; 32(19-20): 1358, 2018 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-30275045

18.

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.

Jethwa, Alexander; Slabicki, Mikolaj; Hüllein, Jennifer; Jentzsch, Marius; Dalal, Vineet; Rabe, Sophie; Wagner, Lena; Walther, Tatjana; Klapper, Wolfram; Bohnenberger, Hanibal; Rettel, Mandy; Lu, Junyan; Smits, Arne H; Stein, Frank; Savitski, Mikhail M; Huber, Wolfgang; Aylon, Yael; Oren, Moshe; Zenz, Thorsten.

Blood ; 131(25): 2789-2802, 2018 06 21.

Artigo em Inglês | MEDLINE | ID: mdl-29653964

19.

Nucleosome organization affects the sensitivity of gene expression to promoter mutations.

Hornung, Gil; Oren, Moshe; Barkai, Naama.

Mol Cell ; 46(3): 362-8, 2012 May 11.

Artigo em Inglês | MEDLINE | ID: mdl-22464732

20.

Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis.

Golomb, Lior; Bublik, Debora Rosa; Wilder, Sylvia; Nevo, Reinat; Kiss, Vladimir; Grabusic, Kristina; Volarevic, Sinisa; Oren, Moshe.

Mol Cell ; 45(2): 222-32, 2012 Jan 27.

Artigo em Inglês | MEDLINE | ID: mdl-22284678

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p53: A tale of complexity and context.

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.

Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.

The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.

p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins.

p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity.

ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP.

TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment.

The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.

Down-regulation of LATS kinases alters p53 to promote cell migration.

Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia.

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.

Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features.

Corrigendum: p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity.

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.

Nucleosome organization affects the sensitivity of gene expression to promoter mutations.

Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis.