Detalhe da pesquisa
1.
Examining Ligand-Based Stabilization of Proteins in Cells with MEK1 Kinase Inhibitors.
Assay Drug Dev Technol
; 13(5): 266-76, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26107610
2.
Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
J Med Chem
; 57(20): 8249-67, 2014 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25271963
3.
AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer.
Cancer Discov
; 4(9): 1046-61, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24893891
4.
Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR).
J Med Chem
; 56(17): 7025-48, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23930994
5.
Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase.
J Med Chem
; 55(11): 5003-12, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22612866