Detalhe da pesquisa
1.
Collective Synthesis of Sarpagine and Macroline Alkaloid-Inspired Compounds.
Chemistry
; 30(5): e202303027, 2024 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37755456
2.
Identification of Biologically Diverse Tetrahydronaphthalen-2-ols through the Synthesis and Phenotypic Profiling of Chemically Diverse, Estradiol-Inspired Compounds.
Chembiochem
; 24(5): e202200555, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36594441
3.
Inducin Triggers LC3-Lipidation and ESCRT-Mediated Lysosomal Membrane Repair.
Chembiochem
; 24(24): e202300579, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37869939
4.
Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp3 -Rich Compounds With Distinct Phenotypic Effects.
Chemistry
; 29(26): e202203992, 2023 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36722618
5.
Morphological Profiling Identifies the Motor Protein Eg5 as Cellular Target of Spirooxindoles.
Angew Chem Int Ed Engl
; 62(21): e202301955, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36929571
6.
Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space.
Angew Chem Int Ed Engl
; 62(48): e202310222, 2023 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37818743
7.
Identification of Dihydroorotate Dehydrogenase Inhibitors Using the Cell Painting Assay.
Chembiochem
; 23(22): e202200475, 2022 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36134475
8.
Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone.
Chemistry
; 28(67): e202202164, 2022 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36083197
9.
Pseudonatural Products Occur Frequently in Biologically Relevant Compounds.
J Chem Inf Model
; 61(11): 5458-5468, 2021 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34669418
10.
Combination of Pseudo-Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo-Sesquiterpenoid Alkaloids.
Angew Chem Int Ed Engl
; 60(39): 21384-21395, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34297473
11.
Design, Synthesis, and Biological Evaluation of Chemically and Biologically Diverse Pyrroquinoline Pseudo Natural Products.
Angew Chem Int Ed Engl
; 60(9): 4648-4656, 2021 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33200868
12.
Morphological Profiling Identifies a Common Mode of Action for Small Molecules with Different Targets.
Chembiochem
; 21(22): 3197-3207, 2020 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32618075
13.
Phenotyping Reveals Targets of a Pseudo-Natural-Product Autophagy Inhibitor.
Angew Chem Int Ed Engl
; 59(30): 12470-12476, 2020 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32108411
14.
Image-Based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor.
Angew Chem Int Ed Engl
; 59(14): 5721-5729, 2020 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31769920
15.
A Scaffold-Diversity Synthesis of Biologically Intriguing Cyclic Sulfonamides.
Chemistry
; 25(68): 15498-15503, 2019 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31518018
16.
Design, Synthesis, and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products.
Angew Chem Int Ed Engl
; 58(41): 14715-14723, 2019 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31339620
17.
Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3.
Angew Chem Int Ed Engl
; 58(47): 17016-17025, 2019 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31469221
18.
Selective Activation of Human Caseinolytic Proteaseâ P (ClpP).
Angew Chem Int Ed Engl
; 57(44): 14602-14607, 2018 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30129683
19.
Exploring Natural Product Fragments for Drug and Probe Discovery.
Chimia (Aarau)
; 71(10): 653-660, 2017 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29070410
20.
Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization.
J Am Chem Soc
; 137(26): 8475-83, 2015 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26083639