Detalhe da pesquisa
1.
Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947.
Bioorg Med Chem Lett
; 30(21): 127574, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32980512
2.
The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics.
Bioorg Med Chem Lett
; 27(4): 1109-1114, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28111141
3.
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.
Bioorg Med Chem Lett
; 27(11): 2559-2566, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28431879
4.
The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.
J Pharmacol Exp Ther
; 359(1): 194-206, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27432892
5.
Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.
Bioorg Med Chem Lett
; 26(9): 2339-43, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27017115
6.
Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.
Bioorg Med Chem Lett
; 26(23): 5695-5702, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27839686
7.
Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis.
J Pharmacol Exp Ther
; 348(1): 153-64, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24142912
8.
Evaluation of selective inhibitors of 11ß-HSD1 for the treatment of hypertension.
Bioorg Med Chem Lett
; 23(12): 3650-3, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23659858
9.
Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.
Bioorg Med Chem Lett
; 23(21): 5829-32, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24075732
10.
Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.
J Med Chem
; 64(11): 7691-7701, 2021 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34038119
11.
A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett
; 19(19): 5716-21, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700315
12.
Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett
; 19(13): 3398-404, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19481932
13.
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett
; 19(18): 5314-20, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19682899
14.
Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.
ACS Med Chem Lett
; 7(7): 697-701, 2016 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27437080
15.
Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus.
Biol Psychiatry
; 57(8): 943-6, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15820718
16.
Estrogen receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe.
Biol Psychiatry
; 57(8): 938-42, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15820717
17.
Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
ACS Med Chem Lett
; 6(8): 861-5, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26288685
18.
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.
ACS Med Chem Lett
; 6(7): 747-52, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26191360
19.
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
ACS Med Chem Lett
; 6(5): 573-8, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26005536
20.
Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.
J Med Chem
; 47(9): 2171-5, 2004 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15084115