Detalhe da pesquisa
1.
Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations.
Cancer Discov
; 14(2): 227-239, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37916958
2.
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov
; 14(2): 240-257, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37916956
3.
Senescence: the good the bad and the dysfunctional.
Curr Opin Genet Dev
; 18(1): 42-7, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18262406
4.
Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators.
Nat Commun
; 10(1): 137, 2019 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30635584
5.
c-Myb and C/EBPß regulate OPN and other senescence-associated secretory phenotype factors.
Oncotarget
; 9(1): 21-36, 2018 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29416593
6.
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.
Nat Med
; 24(4): 497-504, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29457796
7.
AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.
Cancer Res
; 76(11): 3307-18, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27020862
8.
p38MAPK plays a crucial role in stromal-mediated tumorigenesis.
Cancer Discov
; 4(6): 716-29, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24670723
9.
Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression.
Cancer Res
; 72(9): 2251-61, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22422937
10.
Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway.
Mol Cancer Res
; 9(8): 1018-29, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21673011
11.
Senescent stromal-derived osteopontin promotes preneoplastic cell growth.
Cancer Res
; 69(3): 1230-9, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19155301